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Title of Dataset
Data from: Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI
Author of Dataset
Tsai, Vicky Wang-Wei1
Macia, Laurence2
Feinle-Bisset, Christine3
Manandhar, Rakesh1
Astrup, Arne4
Raben, Anne4
Lorenzen, Janne Kunchel4
Schmidt, Peter T.5
Wiklund, Fredrik6
Pedersen, Nancy L.6
Campbell, Lesley7
Kriketos, Adamandia7
Xu, Aimin8
Zhou Pengcheng8
Jia, Weiping9
Curmi, Paul M. G.10
Angstmann, Christopher N.11
Lee-Ng, Ka Ki Michelle1
Zhang, Hong Ping1
Marquis, Christopher P.12
Husaini, Yasmin1
Beglinger, Christoph13
Lin, Shu14
Herzog, Herbert14
Brown, David A.1
Sainsbury, Amanda15
Breit, Samuel N.1
Contact
Tsai, Vicky Wang-Wei1
Breit, Samuel N.1
Date of Dataset Creation
2015-06-10
Description
The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in the hypothalamus and brainstem. More recent studies in germline gene deleted mice also suggest that this cytokine may play a role in physiological regulation of energy homeostasis.
Citation
Tsai, VWW, Macia, L, Feinle-Bisset, C, Manandhar, R, Astrup, A, Raben, A, Lorenzen, JK, Schmidt, PT, Wiklund, F, Pedersen, NL, Campbell, L, Kriketos, A, Xu, A, Zhou Pengcheng, Jia, W, Curmi, PMG, Angstmann, CN, Lee-Ng, KKM, Zhang, HP, Marquis, CP, Husaini, Y, Beglinger, C, Lin, S, Herzog, H, Brown, DA, Sainsbury, A, Breit, SN. (2015). Data from: Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI. [Data File]. All data files are available from the figshare.com database. Click on “Linked Publications” to access the publication and access supporting information on figshare at http://dx.doi.org/10.6084/m9.figshare.1443588.
Subject (RGC Codes)
M2 — Medicine, Dentistry & Health — 醫學, 牙科學及保健
  • 1204 — Cancer — 癌症
Subject (ANZSRC)
10 — TECHNOLOGY — 科技
  • 1004 — MEDICAL BIOTECHNOLOGY — 醫學生物科技
    • 100401 — Gene and Molecular Therapy — 基因及分子療法
Keyword
MIC-1/GDF15
DOI for Dataset
http://dx.doi.org/10.6084/m9.figshare.1443588.v1
Affiliations
  1. St Vincents Hosp, St Vincents Ctr Appl Med Res, Sydney, NSW 2010, Australia ; Univ New S Wales, Sydney, NSW, Australia
  2. Monash Univ, Sch Biomed Sci, Ctr Immunol & Inflammat, Clayton, Vic, Australia
  3. Univ Adelaide, Discipline Med, Adelaide, SA, Australia
  4. Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark
  5. Karolinska Univ Hosp, Dept Med, Unit Gastroenterol & Hepatol, Stockholm, Sweden
  6. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
  7. Garvan Inst Med Res, Diabet & Metab Div, Sydney, NSW, Australia
  8. Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China ; Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China
  9. Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Shanghai Clin Ctr Diabet,Dept Endocrinol & Metab, Shanghai 200030, Peoples R China
  10. Univ New S Wales, Sch Phys, Sydney, NSW, Australia
  11. Univ New S Wales, Sch Math & Stat, Sydney, NSW, Australia
  12. Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia
  13. Univ Basel Hosp, Dept Biomed, Clin Res Ctr, CH-4031 Basel, Switzerland
  14. Garvan Inst Med Res, Div Neurosci, Sydney, NSW, Australia
  15. Univ Sydney, Sydney Med Sch, Boden Inst Obes Nutr Exercise & Eating Disorders, Sydney, NSW 2006, Australia