Rationalizing scaffold design with optimal cell niche for mesenchymal stem cell-based therapy in disc degeneration

Professor Chan, Barbara Pui   (Principal Investigator (PI))

Professor Du Yanan   (Co-principal investigator)

48

2015-01-01

1098911

Rationalizing scaffold design with optimal cell niche for mesenchymal stem cell-based therapy in disc degeneration

intervertebral disc degeneration, mesenchymal stem cell, multiphoton photochemical crosslinking, Stem cell niche

Biomedical Engineering,Biomaterials

Engineering (E)

N_HKU713/14

NSFC/RGC Joint Research Scheme

2014

Completed

1) To screen for the optimal cell niche maintaining phenotype and function of NP cells; 2) To study MSC fate and phenotypic changes upon exposure to the optimal cell niche; 3) To translate the optimal cell niche into scaffold design for IVD tissue engineering