Professor Chan, Daniel Tak Mao 陳德茂
Professor Chan, Daniel Tak Mao 陳德茂
Professor Tak Mao Daniel Chan is currently Chair Professor, Yu Chiu Kwong Professor in Medicine, and Chief of Nephrology Division in the Department of Medicine at the University of Hong Kong and Hong Kong West Cluster Hospitals. He received his training in Nephrology and Internal Medicine at the University of Hong Kong and Guy’s Hospital, London, UK.
Prof Chan's research interests include:
clinical management of lupus nephritis
immuno-pathogenesis of lupus nephritis and chronic kidney diseases focusing on mechanisms leading to renal fibrosis
management of viral hepatitis in patients with chronic kidney disease
The team is internationally recognized for their clinical and translational research in lupus nephritis. Since the mid-1990s TM Chan’s team has published on clinical management regimens including the landmark paper in 2000 in the New England Journal of Medicine which led to establishment of mycophenolate as a new treatment paradigm for lupus nephritis. The team has also established the long-term safety and efficacy of mycophenolate as maintenance immunosuppression, and has investigated novel treatments including tacrolimus and mTOR inhibitors, with publications in J Am Soc Nephrol, Nature Rev Nephrol, Rheumatology, etc. TM Chan is the Lead Author for the Chapter on Lupus Nephritis in the latest version of KDIGO Clinical Management Guidelines for Glomerulonephritis, to be published in 2019/20.
The team’s translational and basic research focuses on immuno-pathogenesis of lupus nephritis and mechanisms leading to kidney fibrosis in chronic kidney disease due to lupus nephritis or other glomerular diseases. Their findings include the discovery that human anti-dsDNA antibodies could bind to glomerular mesangial cell membrane annexin II and get transported into the cytoplasmic and nuclear compartments leading to downstream cellular responses that contribute towards a pro-inflammatory and pro-fibrotic cellular phenotype. Their work using animal models examined the effects of novel treatments for lupus nephritis and mechanisms leading to kidney fibrosis and chronic kidney disease. The results have been published in J Am Soc Nephrol, Arthritis Rheum, Kidney Int, and other leading nephrology, rheumatology, or translational medicine journals.
TM Chan’s team was among the first in the early 1990s to describe the epidemiology and natural history of hepatitis C infection in dialysis patients and kidney transplant recipients, and is internationally recognized for their work in hepatitis B management in kidney transplant recipients. They were among the first to advocate preventive anti-viral treatment of kidney transplant patients at risk of hepatitis B reactivation, and they reported substantially improved patient survival with their clinical management strategy. The team has published their research output in leading journals including Hepatology, Gastroenterology, Transplantation, American Journal of Transplantation, and Transplant Infectious Disease. TM Chan is also an author for related chapters in UpToDate.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2004-02-01||Emodin abrogates peritoneal dialysate induction of pro-inflammatory/fibrotic mediators and morphological changes in human peritoneal mesothelial cells: 9th Medical Research Conference||Research Achievement|
|1998-12-01||Asia Young Investigator Award||Research Achievement|
|2006-12-01||Outstandind Researcher Award, University of Hong Kong||Research Achievement|
|2001-06-01||Emodin ameliorates glucose-induced excess matrix synthesis by human peritoneal mesothelial cells: Peritoneal Dialysis International||Research Achievement|
|1995-12-01||Sir Patrick Manson Gold Medal (MD thesis): The University of Hong Kong||Others|
|2005-02-01||Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity: 10th Medical Research Conference||Research Achievement|
|1997-12-01||Award for Quality in Service & Management (on behalf of the Renal Unit): Queen Mary Hospital||Others|
|2008-12-01||Professor R Yu Endowment Lecture 2008: Hong Kong Society of Nephrology||Research Achievement|
|1999-12-01||Outstanding Young Researcher Award, 1999: University of Hong Kong||Research Achievement|
|2003-12-01||Sir David Todd Lecture, 2003: Hong Kong College of Physicians||Research Achievement|
|2014-12-01||高等學校科學研究優秀成果獎 (second in team listing, in collaboration with Central South University, Changsha, Hunan, 2014: 國家教育部||Research Achievement|
|Term Period||Position||Professional Societies|
|since 2004||Member||Hong Kong College of Physicians Examinations Committee|
|since 2003||Executive Committee and Council Member||Asian Pacific Society of Nephrology|
|since 2000||Executive Committee and Council Member||Asian Society of Transplantation|
|since 2000||Programme Director and Board Member||Hong Kong College of Physicians Advanced Internal Medicine Board|
|since 1996||Member||Hospital Authority Central Renal Committee|
|since 2002||Honorary Secretary and Executive Committee Member||HKU Medical Alumni Association|
|since 2003||Member||Hospital Authority Training Subcommittee in Internal Medicine|
|since 1996||Programme Director and Board Member||Hong Kong College of Physicians Nephrology Board|
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