DSpace Collection:http://hdl.handle.net/10722/444612024-03-29T15:49:03Z2024-03-29T15:49:03ZMETHODS FOR COMPLEX TISSUE ENGINEERINGhttp://hdl.handle.net/10722/2252672020-06-03T08:20:13Z2013-01-01T00:00:00ZTitle: METHODS FOR COMPLEX TISSUE ENGINEERING
Abstract: A simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.2013-01-01T00:00:00ZPolymeric based and surface treated metallic hybrid materials and fabrication methods thereofhttp://hdl.handle.net/10722/2228162020-06-03T08:20:13Z2012-01-01T00:00:00ZTitle: Polymeric based and surface treated metallic hybrid materials and fabrication methods thereof
Abstract: Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.2012-01-01T00:00:00ZSHAPE MEMORY LOCKING DEVICE FOR ORTHOPEDIC IMPLANTShttp://hdl.handle.net/10722/2105532015-07-17T07:37:49Z2012-01-01T00:00:00ZTitle: SHAPE MEMORY LOCKING DEVICE FOR ORTHOPEDIC IMPLANTS
Abstract: A mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape memory effect and super-elasticity of shape memory materials such as nickel-titanium (nitinol or NiTi) shape-memory-alloy, without the use of typical threaded fastening technique. Advantages are conferred by making the entire device, not just connecting pieces, out of shape memory alloy and having shape memory effect and super-elasticity. Heating the memory head of the device will compress the connection portion without the use of an auxiliary device (e.g. coupling member) so that the connection portion can be completely clamped down by the memory head.; Further advantages are provided through the use of a two-way shape memory effect in which the memory device can be closed or tightened by heating up the ambient temperature, and re-opened by cooling down the temperature.2012-01-01T00:00:00ZFIXATION DEVICEhttp://hdl.handle.net/10722/2105522020-06-03T08:20:13Z2003-01-01T00:00:00ZTitle: FIXATION DEVICE
Abstract: The present invention relates to a fixation device for internallyfixing fractures. The fixation device has an alongated support plate and a transverse plate and a fin member extending transversely from the elongated support plate. The elongated support plate and the transverse plate define a plurality of holes for receiving fixing elements to mount the fixation device onto a bone. The holes can be so located that the fixing elements can prevent the fixation device from rotating relatively to the bone after the fixation device is mounted onto the bone. Additionally, the fin member is formed to be more flexible than the transverse plate. Thereby, the fin member can be bent to conform to the contour of the bone for fixing or stabilizing a fractured fragment. As a result, the fixation device can both support the injured bone and fix/stabilize the fractured fragment.2003-01-01T00:00:00Z