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http://hdl.handle.net/10722/44507
2024-03-29T11:16:55ZCoronary heart disease and dyslipidaemia in Hong Kong: a survey of the knowledge and opinions of medical practitioners
http://hdl.handle.net/10722/267851
Title: Coronary heart disease and dyslipidaemia in Hong Kong: a survey of the knowledge and opinions of medical practitioners
Authors: Wong, SP; Cockram, CS; Janus, ED; Lee, WTK; Leung, WH; Masarei, JRL; Tai, YT; Tomlinson, B
Abstract: A questionnaire covering cardiovascular epidemiology, hyperlipidaemia treatment and laboratory tests attracted 460 replies from 4,100 Hong Kong doctors. Most knew of the low cholesterol levels and low rates of coronary heart disease (CHD) in China. Many did not know about the high levels of CHD in Singapore, the effects of renal disease or alcohol on lipids, and the atherosclerosis regression produced by lowering cholesterol. There was limited access to HDL and LDL cholesterol estimations and an inadequate knowledge of laboratory test limitations. Eighty percent preferred the development of Hong Kong Guidelines for the detection and management of lipid disorders ahead of US and European Guidelines. Ninety percent supported combined individual and population strategies to reduce CHD mortality and morbidity. Some deficiencies in the knowledge of dietary and drug treatment were evident. The study clearly demonstrated (1) deficiencies in knowledge requiring further education and (2) the desire for local Lipid Management Guidelines.
Description: Hong Kong Journals Online (HKJO), the University of Hong Kong Libraries1994-01-01T00:00:00ZAlpha-1-antitrypsin PLowell: a normally functioning variant present in low concentration
http://hdl.handle.net/10722/210364
Title: Alpha-1-antitrypsin PLowell: a normally functioning variant present in low concentration
Authors: Cook, L; Burdon, J; Brenton, S; Janus, ED
Abstract: Background: Alpha-1-antitrypsin deficiency is associated with a high risk for the development of emphysema, particularly for phenotype Pi ZZ, which is both deficient and an abnormal inhibitor of the powerful proteolytic enzyme, human neutrophil elastase. The rare variant PLowell is also expressed at abnormally low levels, but its anti-elastase activity has not been described.
Aim: To study the anti-elastase activity of alpha-1-antitrypsin PLowdl and compare it to the common M, S and Z proteins.
Method: Alpha-1-antitrypsin from a female patient aged 75 years with the rare genotype PLoweU NullBcllingham was studied for its ability to inhibit human neutrophil elastase in a time dependent manner.
Results: PLoweii has near normal function as an inhibitor of human neutrophil elastase with an association rate constant of 7.4 X 106 M'V1 at 25 °C, similar to that of M and S.
Conclusion: Alpha-1-antitrypsin PL is associated with a severe deficiency of alpha-1-antitrypsin similar to Z, but unlike that protein it has near normal function as an anti-elastase.1995-01-01T00:00:00ZImpaired glucose tolerance as a risk factor for diabetes mellitus and hypertension in the Hong Kong Chinese population: a 5-year prospective study
http://hdl.handle.net/10722/57386
Title: Impaired glucose tolerance as a risk factor for diabetes mellitus and hypertension in the Hong Kong Chinese population: a 5-year prospective study
Authors: Wat, NMS; Lam, TH; Janus, ED; Lam, KSL2008-01-01T00:00:00ZThe modernization of Asia: implications for coronary heart disease
http://hdl.handle.net/10722/49426
Title: The modernization of Asia: implications for coronary heart disease
Authors: Janus, ED; Postiglione, A; Singh, RB; Lewis, B1996-01-01T00:00:00Z