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Conference Paper: Factors associated with loss of white matter anisotropy in post-treatment medulloblastoma survivors

TitleFactors associated with loss of white matter anisotropy in post-treatment medulloblastoma survivors
Authors
Khong, PLLeung, LHTChan, GCFKwong, DLWOoi, CGCCao, GLeong Fung, LLY
Issue Date2004
PublisherInternational Society for Magnetic Resonance in Medicine.
Citation
The 12th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2004), Kyoto, Japan, 15-21 May 2004. In Conference Proceedings, 2004, v. 11, p. 1249 How to Cite?
AbstractWe evaluate effects of age at cranial irradiation, time interval since irradiation and irradiation dose on white matter anisotropy in childhood medulloblastoma survivors by computing white matter fractional anisotropy (WM FA) using SPM post-processing functions. Mean percentage change in WM FA of patients compared to controls was -4.4% (sd=7.6%). Using Spearmanís correlation, there were significant associations between percentage reduction of WM FA and age at cranial irradiation (r=0.673, p=0.002) and irradiation dose (r=-0.723, p=<0.001), but not with time interval since irradiation. Multivariate regression analysis confirmed that both factors correlated significantly with percentage reduction of WM FA (adjusted r2=0.516, p=0.001).
Persistent Identifierhttp://hdl.handle.net/10722/105578
ISSN
1545-4436

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorLeong Fung, LLYen_HK
dc.date.accessioned2010-09-25T22:40:00Z-
dc.date.available2010-09-25T22:40:00Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2004), Kyoto, Japan, 15-21 May 2004. In Conference Proceedings, 2004, v. 11, p. 1249-
dc.identifier.issn1545-4436-
dc.identifier.urihttp://hdl.handle.net/10722/105578-
dc.description.abstractWe evaluate effects of age at cranial irradiation, time interval since irradiation and irradiation dose on white matter anisotropy in childhood medulloblastoma survivors by computing white matter fractional anisotropy (WM FA) using SPM post-processing functions. Mean percentage change in WM FA of patients compared to controls was -4.4% (sd=7.6%). Using Spearmanís correlation, there were significant associations between percentage reduction of WM FA and age at cranial irradiation (r=0.673, p=0.002) and irradiation dose (r=-0.723, p=<0.001), but not with time interval since irradiation. Multivariate regression analysis confirmed that both factors correlated significantly with percentage reduction of WM FA (adjusted r2=0.516, p=0.001).-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine.-
dc.relation.ispartofInternational Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition Proceedingsen_HK
dc.titleFactors associated with loss of white matter anisotropy in post-treatment medulloblastoma survivorsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros87728en_HK
dc.identifier.volume11-
dc.identifier.spage1249-
dc.identifier.epage1249-
dc.publisher.placeUnited States-
dc.identifier.issnl1524-6965-

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