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Article: Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans

TitleIntraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans
Authors
Issue Date2010
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal of General Virology, 2010, v. 91 n. 4, p. 1058-1062 How to Cite?
AbstractThe Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another SLCoV strain. Moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human SCoV from the late-phase epidemic. Phylogenetic analysis of the Orf1 region suggested that the human SCoVs are phylogenetically closer to SLCoVs in R. sinicus than to SLCoVs in other Rhinolophus species. These findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs. © 2010 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/125151
ISSN
2019 Impact Factor: 3.376
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
Funding AgencyGrant Number
Chinese Ministry of Science2005CB523004
2008GR1409
National Natural Science Foundation30970137
Technology and Knowledge Innovation ProgramKSCX1-YW-R-07
Funding Information:

This work was jointly funded by a State Key Program for Basic Research grant (2005CB523004) and the International Cooperation Centre Project (2008GR1409) from the Chinese Ministry of Science, the National Natural Science Foundation (30970137) and the Technology and Knowledge Innovation Program Key Project administered by the Chinese Academy of Sciences (KSCX1-YW-R-07).

References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Jen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorWang, Den_HK
dc.contributor.authorXu, Gen_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorZhou, Pen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorLam, TTYen_HK
dc.contributor.authorLeung, FCCen_HK
dc.contributor.authorShi, Zen_HK
dc.date.accessioned2010-10-31T11:14:17Z-
dc.date.available2010-10-31T11:14:17Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal of General Virology, 2010, v. 91 n. 4, p. 1058-1062en_HK
dc.identifier.issn0022-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125151-
dc.description.abstractThe Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another SLCoV strain. Moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human SCoV from the late-phase epidemic. Phylogenetic analysis of the Orf1 region suggested that the human SCoVs are phylogenetically closer to SLCoVs in R. sinicus than to SLCoVs in other Rhinolophus species. These findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs. © 2010 SGM.en_HK
dc.languageengen_HK
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_HK
dc.relation.ispartofJournal of General Virologyen_HK
dc.subject.meshAnimals-
dc.subject.meshBase Sequence-
dc.subject.meshChiroptera - virology-
dc.subject.meshPhylogeny-
dc.subject.meshSARS Virus - classification - genetics-
dc.titleIntraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humansen_HK
dc.typeArticleen_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailLam, TTY: ttylam@hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityLam, TTY=rp01733en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1099/vir.0.016378-0en_HK
dc.identifier.pmid20016037-
dc.identifier.scopuseid_2-s2.0-77949532150en_HK
dc.identifier.hkuros176296en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949532150&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1058en_HK
dc.identifier.epage1062en_HK
dc.identifier.isiWOS:000276714300026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuan, J=14065620600en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridLi, Y=36079617800en_HK
dc.identifier.scopusauthoridWang, D=14061500300en_HK
dc.identifier.scopusauthoridXu, G=14049536200en_HK
dc.identifier.scopusauthoridZhang, H=35749213000en_HK
dc.identifier.scopusauthoridZhou, P=7401848795en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridLam, TTY=36775821700en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK
dc.identifier.scopusauthoridShi, Z=7403733955en_HK

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