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- Publisher Website: 10.1021/ol0528641
- Scopus: eid_2-s2.0-33646439990
- PMID: 16597102
- WOS: WOS:000236950400005
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Article: Gold(III) salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction
| Title | Gold(III) salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction |
|---|---|
| Authors | |
| Issue Date | 2006 |
| Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html |
| Citation | Organic Letters, 2006, v. 8 n. 8, p. 1529-1532 How to Cite? |
| Abstract | Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40 °C. With chiral prolinol derivatives as the amine component, excellent diastereoselectivities (up to 99:1) have been attained. This coupling reaction has been applied to the synthesis of propargylamine-modified artemisinin derivatives with the delicate endoperoxide moieties remaining intact. Cytotoxicities with IC 50 values up to 1.1 μM against a human hepatocellular carcinoma cell line (HepG2) were exhibited by these artemisinin derivatives. © 2006 American Chemical Society. |
| Persistent Identifier | http://hdl.handle.net/10722/129112 |
| ISSN | 2021 Impact Factor: 6.072 2020 SCImago Journal Rankings: 1.940 |
| ISI Accession Number ID | |
| References |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lo, VKY | en_HK |
| dc.contributor.author | Liu, Y | en_HK |
| dc.contributor.author | Wong, MK | en_HK |
| dc.contributor.author | Che, CM | en_HK |
| dc.date.accessioned | 2010-12-23T08:32:42Z | - |
| dc.date.available | 2010-12-23T08:32:42Z | - |
| dc.date.issued | 2006 | en_HK |
| dc.identifier.citation | Organic Letters, 2006, v. 8 n. 8, p. 1529-1532 | en_HK |
| dc.identifier.issn | 1523-7060 | en_HK |
| dc.identifier.uri | http://hdl.handle.net/10722/129112 | - |
| dc.description.abstract | Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40 °C. With chiral prolinol derivatives as the amine component, excellent diastereoselectivities (up to 99:1) have been attained. This coupling reaction has been applied to the synthesis of propargylamine-modified artemisinin derivatives with the delicate endoperoxide moieties remaining intact. Cytotoxicities with IC 50 values up to 1.1 μM against a human hepatocellular carcinoma cell line (HepG2) were exhibited by these artemisinin derivatives. © 2006 American Chemical Society. | en_HK |
| dc.language | eng | en_US |
| dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html | en_HK |
| dc.relation.ispartof | Organic Letters | en_HK |
| dc.subject.mesh | Artemisinins - chemical synthesis - chemistry - pharmacology | - |
| dc.subject.mesh | Gold - chemistry | - |
| dc.subject.mesh | Lactones - chemical synthesis - chemistry - pharmacology | - |
| dc.subject.mesh | Pargyline - analogs and derivatives - chemical synthesis - chemistry | - |
| dc.subject.mesh | Propylamines - chemical synthesis - chemistry | - |
| dc.title | Gold(III) salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction | en_HK |
| dc.type | Article | en_HK |
| dc.identifier.email | Liu, Y:lyg100@hku.hk | en_HK |
| dc.identifier.email | Che, CM:cmche@hku.hk | en_HK |
| dc.identifier.authority | Liu, Y=rp00749 | en_HK |
| dc.identifier.authority | Che, CM=rp00670 | en_HK |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1021/ol0528641 | en_HK |
| dc.identifier.pmid | 16597102 | - |
| dc.identifier.scopus | eid_2-s2.0-33646439990 | en_HK |
| dc.identifier.hkuros | 177353 | en_US |
| dc.identifier.hkuros | 148217 | - |
| dc.identifier.hkuros | 127531 | - |
| dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33646439990&selection=ref&src=s&origin=recordpage | en_HK |
| dc.identifier.volume | 8 | en_HK |
| dc.identifier.issue | 8 | en_HK |
| dc.identifier.spage | 1529 | en_HK |
| dc.identifier.epage | 1532 | en_HK |
| dc.identifier.isi | WOS:000236950400005 | - |
| dc.publisher.place | United States | en_HK |
| dc.identifier.scopusauthorid | Lo, VKY=13406071200 | en_HK |
| dc.identifier.scopusauthorid | Liu, Y=8225912600 | en_HK |
| dc.identifier.scopusauthorid | Wong, MK=7403908449 | en_HK |
| dc.identifier.scopusauthorid | Che, CM=7102442791 | en_HK |
| dc.identifier.issnl | 1523-7052 | - |