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Article: The Metabolic syndrome is associated with subclinical atherosclerosis independent of insulin resistance: The Guangzhou Biobank Cohort Study-CVD

TitleThe Metabolic syndrome is associated with subclinical atherosclerosis independent of insulin resistance: The Guangzhou Biobank Cohort Study-CVD
Authors
Xu, LJiang, CQLam, THLin, JMYue, XJCheng, KKLiu, BJin, YLZhang, WSThomas, GN
Issue Date2010
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 2010, v. 73 n. 2, p. 181-188 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1365-2265.2009.03760.x
AbstractObjective We examined whether the association of the metabolic syndrome (MetS) and subclinical atherosclerosis is independent of insulin resistance in a Chinese community sample with no history of type 2 diabetes. Methods Five hundred and ninety-six men and 526 women from a substudy of the Guangzhou Biobank Cohort Study (GBCS-CVD) had carotid intimal-medial thickness (IMT) measured by B-mode ultrasonography, and brachial-ankle pulse wave velocity (PWV) and ankle-brachial systolic blood pressure index (ABI) measured simultaneously by a noninvasive automatic waveform analyser. Results Fourteen percentage had MetS as defined by the International Diabetes Federation. Obesity indices, systolic and diastolic blood pressure and pulse pressure, lipids, fasting and postload glucose and insulin, homeostatic model assessment of insulin resistance, glycosylated haemoglobin A1c, leptin, high-sensitivity C-reactive protein, IMT and PWV increased and high-density lipoprotein-cholesterol, adiponectin and ABI decreased significantly with increasing number of MetS components after adjusting for age and sex (P for trend from 0·004 to <0·001). After adjusting for traditional cardiovascular risk factors and insulin resistance, the odds ratios [OR (95% CI)] of thicker IMT (≥1·0 mm), higher PWV (≥14·0 ms) and low ABI (≤1·0) for MetS were significantly increased [2.28 (1.19-4.38), 2.17 (1.36-3.46) and 1.72 (1.14-2.59), respectively, all P < 0.01] but were lower than the adjusted OR for those with three or more MetS components. Conclusion MetS was associated with subclinical atherosclerosis independent of insulin resistance. The presence of increasing number of MetS risk factors appeared to be more important than the diagnosis of MetS in predicting subclinical atherosclerosis. Early screening for MetS risk factors might identify those at greater cardiovascular risk. © 2010 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/129483
ISSN
0300-0664
2021 Impact Factor: 3.523
2020 SCImago Journal Rankings: 1.055
ISI Accession Number ID
WOS:000280197900008
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council30518001
HKU720/05
The University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
The University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science Foundation of China/Research Grants Council (No. 30518001; HKU720/05) grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include: Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (Co-PI); The University of Hong Kong: Tai Hing Lam (Co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Bernard MY Cheung, Shahrad Taheri, Paramjit Gill, Greg YH Lip, Kar Keung Cheng, G Neil Thomas (Co-PI).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorXu, Len_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorYue, XJen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorJin, YLen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2010-12-23T08:37:51Z-
dc.date.available2010-12-23T08:37:51Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical Endocrinology, 2010, v. 73 n. 2, p. 181-188en_HK
dc.identifier.issn0300-0664en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129483-
dc.description.abstractObjective We examined whether the association of the metabolic syndrome (MetS) and subclinical atherosclerosis is independent of insulin resistance in a Chinese community sample with no history of type 2 diabetes. Methods Five hundred and ninety-six men and 526 women from a substudy of the Guangzhou Biobank Cohort Study (GBCS-CVD) had carotid intimal-medial thickness (IMT) measured by B-mode ultrasonography, and brachial-ankle pulse wave velocity (PWV) and ankle-brachial systolic blood pressure index (ABI) measured simultaneously by a noninvasive automatic waveform analyser. Results Fourteen percentage had MetS as defined by the International Diabetes Federation. Obesity indices, systolic and diastolic blood pressure and pulse pressure, lipids, fasting and postload glucose and insulin, homeostatic model assessment of insulin resistance, glycosylated haemoglobin A1c, leptin, high-sensitivity C-reactive protein, IMT and PWV increased and high-density lipoprotein-cholesterol, adiponectin and ABI decreased significantly with increasing number of MetS components after adjusting for age and sex (P for trend from 0·004 to <0·001). After adjusting for traditional cardiovascular risk factors and insulin resistance, the odds ratios [OR (95% CI)] of thicker IMT (≥1·0 mm), higher PWV (≥14·0 ms) and low ABI (≤1·0) for MetS were significantly increased [2.28 (1.19-4.38), 2.17 (1.36-3.46) and 1.72 (1.14-2.59), respectively, all P < 0.01] but were lower than the adjusted OR for those with three or more MetS components. Conclusion MetS was associated with subclinical atherosclerosis independent of insulin resistance. The presence of increasing number of MetS risk factors appeared to be more important than the diagnosis of MetS in predicting subclinical atherosclerosis. Early screening for MetS risk factors might identify those at greater cardiovascular risk. © 2010 Blackwell Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_HK
dc.relation.ispartofClinical Endocrinologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshAtherosclerosis - complications - epidemiology - etiology - metabolism-
dc.subject.meshCardiovascular Diseases - epidemiology - etiology-
dc.subject.meshInsulin Resistance - physiology-
dc.subject.meshMetabolic Syndrome X - complications - epidemiology - metabolism-
dc.subject.meshObesity - complications - epidemiology - metabolism-
dc.titleThe Metabolic syndrome is associated with subclinical atherosclerosis independent of insulin resistance: The Guangzhou Biobank Cohort Study-CVDen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-0664&volume=73&issue=2&spage=181&epage=188&date=2010&atitle=The+metabolic+syndrome+is+associated+with+subclinical+atherosclerosis+independent+of+insulin+resistance:+The+Guangzhou+Biobank+Cohort+Study-CVD-
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2265.2009.03760.xen_HK
dc.identifier.pmid20039893-
dc.identifier.scopuseid_2-s2.0-77954868505en_HK
dc.identifier.hkuros183397en_US
dc.identifier.hkuros179993-
dc.identifier.hkuros183476-
dc.identifier.hkuros180640-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954868505&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume73en_HK
dc.identifier.issue2en_HK
dc.identifier.spage181en_HK
dc.identifier.epage188en_HK
dc.identifier.isiWOS:000280197900008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXu, L=7404744449en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLin, JM=35409737900en_HK
dc.identifier.scopusauthoridYue, XJ=35410971600en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridLiu, B=36079151900en_HK
dc.identifier.scopusauthoridJin, YL=35558481400en_HK
dc.identifier.scopusauthoridZhang, WS=13410704100en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.citeulike7617242-
dc.identifier.issnl0300-0664-

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