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Article: Severe liver disease in pregnancy

TitleSevere liver disease in pregnancy
Authors
Chen, HYuan, LTan, JLiu, YZhang, J
KeywordsCesarean Section
Clinical Feature
Disease Severity
Fatty Liver
Hepatic Encephalopathy
Hepatitis
Human
Maternal Mortality
Note
Postpartum Hemorrhage
Pregnancy Outcome
Prenatal Screening
Primigravida
Issue Date2008
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijgo
Citation
International Journal Of Gynecology And Obstetrics, 2008, v. 101 n. 3, p. 277-280 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ijgo.2007.12.011
AbstractObjective: To determine the clinical characteristics of patients with fulminant hepatitis of pregnancy (FHP) and acute fatty liver of pregnancy (AFLP) and analyze their correlation with pregnancy outcome. Methods: Of 55 pregnant women with severe liver disease, 41 had FHP and 14 had AFLP. Results: Jaundice was the primary manifestation for both FHP and AFLP and hepatic encephalopathy was the most significant complication for both. Disseminated intravascular coagulation, albuminuria, and prothrombin activity were found to be independent risk factors of maternal mortality for both. However, the rates of preterm labor, fetal demise, and neonatal asphyxia were lower in the FHP group. Conclusion: Women with FHP or AFLP are at risk for severe complications and adverse pregnancy outcome. Since the 2 conditions are managed differently, early diagnosis is essential. © 2008 International Federation of Gynecology and Obstetrics.
Persistent Identifierhttp://hdl.handle.net/10722/132668
ISSN
0020-7292
2021 Impact Factor: 4.447
2020 SCImago Journal Rankings: 0.895
ISI Accession Number ID
WOS:000256259100013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChen, Hen_HK
dc.contributor.authorYuan, Len_HK
dc.contributor.authorTan, Jen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorZhang, Jen_HK
dc.date.accessioned2011-03-28T09:27:56Z-
dc.date.available2011-03-28T09:27:56Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Journal Of Gynecology And Obstetrics, 2008, v. 101 n. 3, p. 277-280en_HK
dc.identifier.issn0020-7292en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132668-
dc.description.abstractObjective: To determine the clinical characteristics of patients with fulminant hepatitis of pregnancy (FHP) and acute fatty liver of pregnancy (AFLP) and analyze their correlation with pregnancy outcome. Methods: Of 55 pregnant women with severe liver disease, 41 had FHP and 14 had AFLP. Results: Jaundice was the primary manifestation for both FHP and AFLP and hepatic encephalopathy was the most significant complication for both. Disseminated intravascular coagulation, albuminuria, and prothrombin activity were found to be independent risk factors of maternal mortality for both. However, the rates of preterm labor, fetal demise, and neonatal asphyxia were lower in the FHP group. Conclusion: Women with FHP or AFLP are at risk for severe complications and adverse pregnancy outcome. Since the 2 conditions are managed differently, early diagnosis is essential. © 2008 International Federation of Gynecology and Obstetrics.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijgoen_HK
dc.relation.ispartofInternational Journal of Gynecology and Obstetricsen_HK
dc.subjectCesarean Sectionen_US
dc.subjectClinical Featureen_US
dc.subjectDisease Severityen_US
dc.subjectFatty Liveren_US
dc.subjectHepatic Encephalopathyen_US
dc.subjectHepatitisen_US
dc.subjectHumanen_US
dc.subjectMaternal Mortalityen_US
dc.subjectNoteen_US
dc.subjectPostpartum Hemorrhageen_US
dc.subjectPregnancy Outcomeen_US
dc.subjectPrenatal Screeningen_US
dc.subjectPrimigravidaen_US
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshFatty Liver - complications - mortalityen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFetal Deathen_HK
dc.subject.meshHepatic Encephalopathy - etiology - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshJaundice - etiologyen_HK
dc.subject.meshLiver - physiopathologyen_HK
dc.subject.meshLiver Failure, Acute - complications - mortalityen_HK
dc.subject.meshMaternal Mortalityen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Complications - diagnosis - etiologyen_HK
dc.subject.meshPregnancy Outcomeen_HK
dc.subject.meshRegression Analysisen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleSevere liver disease in pregnancyen_HK
dc.typeArticleen_HK
dc.identifier.emailLiu, Y: liuyukun@hku.hken_HK
dc.identifier.authorityLiu, Y=rp01460en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijgo.2007.12.011en_HK
dc.identifier.pmid18321514-
dc.identifier.scopuseid_2-s2.0-43049097450en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43049097450&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue3en_HK
dc.identifier.spage277en_HK
dc.identifier.epage280en_HK
dc.identifier.eissn1533-9866-
dc.identifier.isiWOS:000256259100013-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChen, H=35227067800en_HK
dc.identifier.scopusauthoridYuan, L=52265085500en_HK
dc.identifier.scopusauthoridTan, J=23391193100en_HK
dc.identifier.scopusauthoridLiu, Y=23667956400en_HK
dc.identifier.scopusauthoridZhang, J=7601343102en_HK

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