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Article: Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

TitleAnalysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease
Authors
Brindle, NSong, YRogaeva, EPremkumar, SLevesque, GYu, GIkeda, MNishimura, MPaterson, ASorbi, SDuara, RFarrer, LSt GeorgeHyslop, P
Issue Date1998
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 1998, v. 7 n. 5, p. 933-935 How to Cite?
DOI: http://dx.doi.org/10.1093/hmg/7.5.933
AbstractThe K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
Persistent Identifierhttp://hdl.handle.net/10722/134760
ISSN
0964-6906
2021 Impact Factor: 5.121
2020 SCImago Journal Rankings: 2.811
ISI Accession Number ID
WOS:000073657000021
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorBrindle, Nen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorRogaeva, Een_HK
dc.contributor.authorPremkumar, Sen_HK
dc.contributor.authorLevesque, Gen_HK
dc.contributor.authorYu, Gen_HK
dc.contributor.authorIkeda, Men_HK
dc.contributor.authorNishimura, Men_HK
dc.contributor.authorPaterson, Aen_HK
dc.contributor.authorSorbi, Sen_HK
dc.contributor.authorDuara, Ren_HK
dc.contributor.authorFarrer, Len_HK
dc.contributor.authorSt GeorgeHyslop, Pen_HK
dc.date.accessioned2011-07-14T07:02:53Z-
dc.date.available2011-07-14T07:02:53Z-
dc.date.issued1998en_HK
dc.identifier.citationHuman Molecular Genetics, 1998, v. 7 n. 5, p. 933-935en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134760-
dc.description.abstractThe K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.en_HK
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshAlzheimer Disease/enzymology/*geneticsen_US
dc.subject.meshApolipoprotein E4en_US
dc.subject.meshApolipoproteins E/geneticsen_US
dc.subject.meshButyrylcholinesterase/*geneticsen_US
dc.subject.meshChromosomes, Human, Pair 3/*geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAnalysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailSong, Y: songy@hkucc.hku.hken_US
dc.identifier.authoritySong, Y=rp00488en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/hmg/7.5.933en_HK
dc.identifier.pmid9536099-
dc.identifier.scopuseid_2-s2.0-7144262433en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7144262433&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue5en_HK
dc.identifier.spage933en_HK
dc.identifier.epage935en_HK
dc.identifier.isiWOS:000073657000021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.issnl0964-6906-

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