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Article: Reversible leukoencephalopathy following intrathecal methotrexate

TitleReversible leukoencephalopathy following intrathecal methotrexate
Authors
Xiong, HHa, SYChiang, AKSLau, YLHu, QChan, GCF
KeywordsIntrathecal
Leukoencephalopathy
Magnetic resonance imaging
Methotrexate
Issue Date2010
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2010, v. 15 n. 4, p. 327-331 How to Cite?
AbstractLeukoencephalopathy is a severe but often reversible neurological complication with high dose intravenous methotrexate (MTX). It is much rarer after intrathecal MTX. We report a 13-year-old girl suffered from leukoencephalopathy 7 days after intrathecal MTX administration. The sequential MRI changes are highlighted in this report. Rescue therapy with aminophylline and high-dose folinic acid was given for 10 days. Her neurological status in terms of the speech and motor function gradually improved afterwards.
Persistent Identifierhttp://hdl.handle.net/10722/135325
ISSN
1013-9923
2021 Impact Factor: 0.104
2020 SCImago Journal Rankings: 0.115
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorXiong, Hen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorHu, Qen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2011-07-27T01:33:37Z-
dc.date.available2011-07-27T01:33:37Z-
dc.date.issued2010en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2010, v. 15 n. 4, p. 327-331en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135325-
dc.description.abstractLeukoencephalopathy is a severe but often reversible neurological complication with high dose intravenous methotrexate (MTX). It is much rarer after intrathecal MTX. We report a 13-year-old girl suffered from leukoencephalopathy 7 days after intrathecal MTX administration. The sequential MRI changes are highlighted in this report. Rescue therapy with aminophylline and high-dose folinic acid was given for 10 days. Her neurological status in terms of the speech and motor function gradually improved afterwards.en_HK
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.rightsDOAJen_US
dc.subjectIntrathecalen_HK
dc.subjectLeukoencephalopathyen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectMethotrexateen_HK
dc.titleReversible leukoencephalopathy following intrathecal methotrexateen_HK
dc.typeArticleen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-78149451909en_HK
dc.identifier.hkuros186674en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78149451909&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage327en_HK
dc.identifier.epage331en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridXiong, H=36438003100en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridHu, Q=35080358400en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.issnl1013-9923-

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