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Article: Effects of strontium in modified biomaterials

TitleEffects of strontium in modified biomaterials
Authors
Zhang, WShen, YPan, HLin, KLiu, XDarvell, BWLu, WWChang, JDeng, LWang, DHuang, W
KeywordsBioactivity
Borosilicate
Calcium silicate
Hydroxyapatite
Strontium
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2011, v. 7 n. 2, p. 800-808 How to Cite?
DOI: http://dx.doi.org/10.1016/j.actbio.2010.08.031
AbstractStrontium (Sr) plays a special role in bone remodelling, being associated with both the stimulation of bone formation and a reduction in bone resorption. Thus, the modification of biomaterials by partial or full substitution by Sr is expected to increase both bioactivity and biocompatibility. However, such effects have to be studied individually. Although no phase transition was found in Sr-substituted hydroxyapatite (Sr-HA), Sr-containing calcium silicate (Sr-CS) or Sr-containing borosilicate (Sr-BS), their biological performance was substantially affected by changes in the physico-chemical properties and Sr content of the materials. Three distinct outcomes were found for the presence of Sr: (1) increased HA solubility; (2) no significant effect on the degradation rate of CS; (3) apparent inhibition of the otherwise rapid degradation of BS. In each case the released Sr affected osteoblast proliferation and alkaline phosphatase activity, with clear evidence that an optimum Sr dose exists. Such chemical and biological variations must be disentangled for the behaviour to be properly understood and materials design to be advanced. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/142248
ISSN
1742-7061
2021 Impact Factor: 10.633
2020 SCImago Journal Rankings: 1.944
ISI Accession Number ID
WOS:000286707700037
Funding AgencyGrant Number
Science and Technology Commission of Shanghai Municipality09JC1415500
084411900500
Natural Science Foundation of China30900299
51072133
Hong Kong RGCHKU7147/07E
Funding Information:

This work was funded by grants from Science and Technology Commission of Shanghai Municipality (Grants Nos. 09JC1415500 and 084411900500), Natural Science Foundation of China (Grants Nos. 30900299 and 51072133) and Hong Kong RGC HKU7147/07E.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorZhang, Wen_HK
dc.contributor.authorShen, Yen_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorLin, Ken_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorDarvell, BWen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChang, Jen_HK
dc.contributor.authorDeng, Len_HK
dc.contributor.authorWang, Den_HK
dc.contributor.authorHuang, Wen_HK
dc.date.accessioned2011-10-26T08:08:38Z-
dc.date.available2011-10-26T08:08:38Z-
dc.date.issued2011en_HK
dc.identifier.citationActa Biomaterialia, 2011, v. 7 n. 2, p. 800-808en_HK
dc.identifier.issn1742-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142248-
dc.description.abstractStrontium (Sr) plays a special role in bone remodelling, being associated with both the stimulation of bone formation and a reduction in bone resorption. Thus, the modification of biomaterials by partial or full substitution by Sr is expected to increase both bioactivity and biocompatibility. However, such effects have to be studied individually. Although no phase transition was found in Sr-substituted hydroxyapatite (Sr-HA), Sr-containing calcium silicate (Sr-CS) or Sr-containing borosilicate (Sr-BS), their biological performance was substantially affected by changes in the physico-chemical properties and Sr content of the materials. Three distinct outcomes were found for the presence of Sr: (1) increased HA solubility; (2) no significant effect on the degradation rate of CS; (3) apparent inhibition of the otherwise rapid degradation of BS. In each case the released Sr affected osteoblast proliferation and alkaline phosphatase activity, with clear evidence that an optimum Sr dose exists. Such chemical and biological variations must be disentangled for the behaviour to be properly understood and materials design to be advanced. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomaten_HK
dc.relation.ispartofActa Biomaterialiaen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#7, ISSUE#2, (2011)] DOI#10.1016/j.actbio.2010.08.031-
dc.subjectBioactivityen_HK
dc.subjectBorosilicateen_HK
dc.subjectCalcium silicateen_HK
dc.subjectHydroxyapatiteen_HK
dc.subjectStrontiumen_HK
dc.subject.meshBiocompatible Materials - pharmacology-
dc.subject.meshCalcium Compounds - pharmacology-
dc.subject.meshSpectrophotometry, Atomic-
dc.subject.meshSpectroscopy, Fourier Transform Infrared-
dc.subject.meshStrontium - pharmacology-
dc.titleEffects of strontium in modified biomaterialsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7061&volume=7&issue=2&spage=800&epage=808&date=2011&atitle=Effects+of+strontium+in+modified+biomaterials-
dc.identifier.emailPan, H: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.actbio.2010.08.031en_HK
dc.identifier.pmid20826233-
dc.identifier.scopuseid_2-s2.0-78650718376en_HK
dc.identifier.hkuros197046-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650718376&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue2en_HK
dc.identifier.spage800en_HK
dc.identifier.epage808en_HK
dc.identifier.eissn1878-7568-
dc.identifier.isiWOS:000286707700037-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhang, W=36490950900en_HK
dc.identifier.scopusauthoridShen, Y=55492340800en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridLin, K=8893315700en_HK
dc.identifier.scopusauthoridLiu, X=35754729200en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridChang, J=7601548164en_HK
dc.identifier.scopusauthoridDeng, L=7202007494en_HK
dc.identifier.scopusauthoridWang, D=35254296800en_HK
dc.identifier.scopusauthoridHuang, W=7407905904en_HK
dc.identifier.issnl1742-7061-

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