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Article: Inhibition of sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling

TitleInhibition of sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling
Authors
Wu, XPang, LLei, WLu, WLi, JLi, ZFrassica, FJChen, XWan, MCao, X
Issue Date2010
PublisherCell Press. The Journal's web site is located at http://www.cellstemcell.com
Citation
Cell Stem Cell, 2010, v. 7 n. 5, p. 571-580 How to Cite?
DOI: http://dx.doi.org/10.1016/j.stem.2010.09.012
AbstractThe anabolic effects of parathyroid hormone (PTH) on bone formation are impaired by concurrent use of antiresorptive drugs. We found that the release of active transforming growth factor (TGF)-β1 during osteoclastic bone resorption is inhibited by alendronate. We showed that mouse Sca-1-positive (Sca-1 +) bone marrow stromal cells are a skeletal stem cell subset, which are recruited to bone remodeling sites by active TGF-β1 in response to bone resorption. Alendronate inhibits the release of active TGF-β1 and the recruitment of Sca-1 + skeletal stem cells for the bone formation. The observation was validated in a Tgfb1 -/- mouse model, in which the anabolic effects of PTH on bone formation are diminished. The PTH-stimulated recruitment of injected mouse Sca-1 + cells to the resorptive sites was inhibited by alendronate. Thus, inhibition of active TGF-β1 release by alendronate reduces the recruitment of Sca-1 + skeletal stem cells and impairs the anabolic action of PTH in bone. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/142445
ISSN
1934-5909
2021 Impact Factor: 25.269
2020 SCImago Journal Rankings: 8.860
ISI Accession Number ID
WOS:000284390500009
Funding AgencyGrant Number
US National Institutes of HealthDK0080898
AR 053973
Funding Information:

The authors thank Elaine P. Henze (Editorial Services Department of Orthopaedic Surgery, Johns Hopkins University) for editing the manuscript and Dr. Brendan J. Canning (Asthma and Allergy Center, Johns Hopkins University) for providing guinea pig marrow cells. This research was supported by US National Institutes of Health grants DK0080898 and AR 053973 to X. Cao.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWu, Xen_HK
dc.contributor.authorPang, Len_HK
dc.contributor.authorLei, Wen_HK
dc.contributor.authorLu, Wen_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorFrassica, FJen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorWan, Men_HK
dc.contributor.authorCao, Xen_HK
dc.date.accessioned2011-10-28T02:46:08Z-
dc.date.available2011-10-28T02:46:08Z-
dc.date.issued2010en_HK
dc.identifier.citationCell Stem Cell, 2010, v. 7 n. 5, p. 571-580en_HK
dc.identifier.issn1934-5909en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142445-
dc.description.abstractThe anabolic effects of parathyroid hormone (PTH) on bone formation are impaired by concurrent use of antiresorptive drugs. We found that the release of active transforming growth factor (TGF)-β1 during osteoclastic bone resorption is inhibited by alendronate. We showed that mouse Sca-1-positive (Sca-1 +) bone marrow stromal cells are a skeletal stem cell subset, which are recruited to bone remodeling sites by active TGF-β1 in response to bone resorption. Alendronate inhibits the release of active TGF-β1 and the recruitment of Sca-1 + skeletal stem cells for the bone formation. The observation was validated in a Tgfb1 -/- mouse model, in which the anabolic effects of PTH on bone formation are diminished. The PTH-stimulated recruitment of injected mouse Sca-1 + cells to the resorptive sites was inhibited by alendronate. Thus, inhibition of active TGF-β1 release by alendronate reduces the recruitment of Sca-1 + skeletal stem cells and impairs the anabolic action of PTH in bone. © 2010 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.cellstemcell.comen_HK
dc.relation.ispartofCell Stem Cellen_HK
dc.subject.meshAlendronate - pharmacology-
dc.subject.meshBone Remodeling - drug effects-
dc.subject.meshMembrane Proteins-
dc.subject.meshParathyroid Hormone - antagonists and inhibitors-
dc.subject.meshStem Cells - drug effects - physiology-
dc.titleInhibition of sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodelingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1934-5909&volume=7&issue=5&spage=571&epage=580&date=2010&atitle=Inhibition+of+Sca-1-positive+skeletal+stem+cells+recruitment+by+alendronate+blunts+the+anabolic+effects+of+parathyroid+hormone+on+bone+remodeling,-
dc.identifier.emailLu, W:wwlu@hku.hken_HK
dc.identifier.authorityLu, W=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.stem.2010.09.012en_HK
dc.identifier.pmid21040899-
dc.identifier.scopuseid_2-s2.0-78049510298en_HK
dc.identifier.hkuros197080en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78049510298&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue5en_HK
dc.identifier.spage571en_HK
dc.identifier.epage580en_HK
dc.identifier.eissn1934-5909-
dc.identifier.isiWOS:000284390500009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, X=35867626100en_HK
dc.identifier.scopusauthoridPang, L=13307644700en_HK
dc.identifier.scopusauthoridLei, W=28367791400en_HK
dc.identifier.scopusauthoridLu, W=7404215221en_HK
dc.identifier.scopusauthoridLi, J=36062945100en_HK
dc.identifier.scopusauthoridLi, Z=35867304900en_HK
dc.identifier.scopusauthoridFrassica, FJ=7006609242en_HK
dc.identifier.scopusauthoridChen, X=37051752200en_HK
dc.identifier.scopusauthoridWan, M=7202684871en_HK
dc.identifier.scopusauthoridCao, X=7403370374en_HK
dc.identifier.issnl1875-9777-

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