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- Publisher Website: 10.1111/j.1399-0004.1998.tb03752.x
- Scopus: eid_2-s2.0-0031740464
- PMID: 9842991
- WOS: WOS:000076952900003
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Article: Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
Title | Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree |
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Authors | |
Keywords | Genetic variation Paraoxonase-2 Plasma lipoprotein |
Issue Date | 1998 |
Publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGE |
Citation | Clinical Genetics, 1998, v. 54 n. 5, p. 394-399 How to Cite? |
Abstract | We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism. |
Persistent Identifier | http://hdl.handle.net/10722/143118 |
ISSN | 2021 Impact Factor: 4.296 2020 SCImago Journal Rankings: 1.543 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Hegele, RA | en_HK |
dc.contributor.author | Harris, SB | en_HK |
dc.contributor.author | Connelly, PW | en_HK |
dc.contributor.author | Hanley, AJG | en_HK |
dc.contributor.author | Tsui, LC | en_HK |
dc.contributor.author | Zinman, B | en_HK |
dc.contributor.author | Scherer, SW | en_HK |
dc.date.accessioned | 2011-11-01T07:13:09Z | - |
dc.date.available | 2011-11-01T07:13:09Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Clinical Genetics, 1998, v. 54 n. 5, p. 394-399 | en_HK |
dc.identifier.issn | 0009-9163 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/143118 | - |
dc.description.abstract | We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala→Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (ape) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism. | en_HK |
dc.language | eng | - |
dc.publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CGE | en_HK |
dc.relation.ispartof | Clinical Genetics | en_HK |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.subject | Genetic variation | en_HK |
dc.subject | Paraoxonase-2 | en_HK |
dc.subject | Plasma lipoprotein | en_HK |
dc.subject.mesh | Aryldialkylphosphatase | - |
dc.subject.mesh | Esterases - genetics | - |
dc.subject.mesh | Genetic Variation | - |
dc.subject.mesh | Indians, North American - genetics | - |
dc.subject.mesh | Lipoproteins - blood | - |
dc.title | Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-9163&volume=54&issue=5&spage=394&epage=399&date=1998&atitle=Genetic+variation+in+paraoxonase-2+is+associated+with+variation+in+plasma+lipoproteins+in+Canadian+Oji-Cree | - |
dc.identifier.email | Tsui, LC: tsuilc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tsui, LC=rp00058 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1399-0004.1998.tb03752.x | - |
dc.identifier.pmid | 9842991 | - |
dc.identifier.scopus | eid_2-s2.0-0031740464 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031740464&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 54 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 394 | en_HK |
dc.identifier.epage | 399 | en_HK |
dc.identifier.isi | WOS:000076952900003 | - |
dc.publisher.place | Denmark | en_HK |
dc.identifier.scopusauthorid | Hegele, RA=35399481100 | en_HK |
dc.identifier.scopusauthorid | Harris, SB=35500171900 | en_HK |
dc.identifier.scopusauthorid | Connelly, PW=16738577100 | en_HK |
dc.identifier.scopusauthorid | Hanley, AJG=7005599486 | en_HK |
dc.identifier.scopusauthorid | Tsui, LC=7102754167 | en_HK |
dc.identifier.scopusauthorid | Zinman, B=7102090193 | en_HK |
dc.identifier.scopusauthorid | Scherer, SW=35374654500 | en_HK |
dc.identifier.issnl | 0009-9163 | - |