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Article: Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke

TitleMethylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke
Authors
KeywordsElderly
Folate
Methylenetetrahydrofolate reductase (MTHFR)
Mutation
Polymorphism
Stroke
Issue Date2004
PublisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclm
Citation
Clinical Chemistry and Laboratory Medicine, 2004, v. 42 n. 12, p. 1370-1376 How to Cite?
AbstractThe 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor. This polymorphism was examined for association with stroke. In a case-control study of 241 ischemic stroke patients and 304 controls in Hong Kong, the V allele increased in stroke [28% vs. 20%, odds ratio (OR) 1.5, p = 0.003]. A lack of significance for the increase in the VV genotype (7.5% vs. 4.6%, OR 1.7, p=0.16) may be due to its rarity in this region. V-allele carriers had more severe strokes (according to the NIH stroke scale). The association of the V allele with stroke occurred mostly in women or older subjects and was due to decreasing V allele frequency with age, as seen in other studies. This V frequency decline with age might be due to a loss of V-carrying controls from a higher risk of cancer, vascular disease, bone fracture, and kidney failure when folate is sparse. Examination of previous studies revealed that the association of VV genotype with stroke appeared stronger in Japan than elsewhere, possibly due to dietary differences. Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions. © 2004 by Walter de Gruyter.
Persistent Identifierhttp://hdl.handle.net/10722/147516
ISSN
2019 Impact Factor: 3.595
2015 SCImago Journal Rankings: 0.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBaum, Len_US
dc.contributor.authorWong, KSen_US
dc.contributor.authorNg, HKen_US
dc.contributor.authorTomlinson, Ben_US
dc.contributor.authorRainer, THen_US
dc.contributor.authorChan, DKYen_US
dc.contributor.authorThomas, GNen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorPoon, Pen_US
dc.contributor.authorCheung, WSen_US
dc.contributor.authorWoo, KSen_US
dc.date.accessioned2012-05-29T06:04:17Z-
dc.date.available2012-05-29T06:04:17Z-
dc.date.issued2004en_US
dc.identifier.citationClinical Chemistry and Laboratory Medicine, 2004, v. 42 n. 12, p. 1370-1376en_US
dc.identifier.issn1434-6621en_US
dc.identifier.urihttp://hdl.handle.net/10722/147516-
dc.description.abstractThe 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor. This polymorphism was examined for association with stroke. In a case-control study of 241 ischemic stroke patients and 304 controls in Hong Kong, the V allele increased in stroke [28% vs. 20%, odds ratio (OR) 1.5, p = 0.003]. A lack of significance for the increase in the VV genotype (7.5% vs. 4.6%, OR 1.7, p=0.16) may be due to its rarity in this region. V-allele carriers had more severe strokes (according to the NIH stroke scale). The association of the V allele with stroke occurred mostly in women or older subjects and was due to decreasing V allele frequency with age, as seen in other studies. This V frequency decline with age might be due to a loss of V-carrying controls from a higher risk of cancer, vascular disease, bone fracture, and kidney failure when folate is sparse. Examination of previous studies revealed that the association of VV genotype with stroke appeared stronger in Japan than elsewhere, possibly due to dietary differences. Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions. © 2004 by Walter de Gruyter.en_US
dc.languageengen_US
dc.publisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclmen_US
dc.relation.ispartofClinical Chemistry and Laboratory Medicineen_US
dc.subjectElderly-
dc.subjectFolate-
dc.subjectMethylenetetrahydrofolate reductase (MTHFR)-
dc.subjectMutation-
dc.subjectPolymorphism-
dc.subjectStroke-
dc.subject.meshAge Distributionen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAllelesen_US
dc.subject.meshBrain Ischemia - Enzymology - Epidemiology - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHomocysteine - Metabolismen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylenetetrahydrofolate Reductase (Nadph2) - Genetics - Metabolismen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshStroke - Enzymology - Geneticsen_US
dc.titleMethylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic strokeen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1515/CCLM.2004.256en_US
dc.identifier.pmid15576298en_US
dc.identifier.scopuseid_2-s2.0-19944428322en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19944428322&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume42en_US
dc.identifier.issue12en_US
dc.identifier.spage1370en_US
dc.identifier.epage1376en_US
dc.identifier.isiWOS:000225906600004-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridBaum, L=7103310839en_US
dc.identifier.scopusauthoridWong, KS=7404759405en_US
dc.identifier.scopusauthoridNg, HK=7401619354en_US
dc.identifier.scopusauthoridTomlinson, B=16423466900en_US
dc.identifier.scopusauthoridRainer, TH=7004489495en_US
dc.identifier.scopusauthoridChan, DKY=7402216545en_US
dc.identifier.scopusauthoridThomas, GN=35465269900en_US
dc.identifier.scopusauthoridChen, X=13309974700en_US
dc.identifier.scopusauthoridPoon, P=9336837000en_US
dc.identifier.scopusauthoridCheung, WS=7202743145en_US
dc.identifier.scopusauthoridWoo, KS=7202574149en_US

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