Systemic effects of inflammation in bronchiectasis

Abstract

A group of bronchiectatic subjects in the clinically stable state were studied for systemic evidence of inflammation. The following parameters were evaluated: body weight, serum albumin, serum globulin, serum alpha 1 antitrypsin (α 1AT) and peripheral white cell count. For serum albumin and globulin, comparison was made between subjects with bronchiectasis and control subjects with no known pulmonary disease matched for sex and age, and for serum α 1AT and peripheral white cell count, matched for smoking habit as well. The bronchiectatic subjects showed systemic effects of inflammation as indicated by lower body weight and serum albumin (P<0.01), higher serum globulin (P<0.001), serum α 1AT (P<0.05) and total leucocyte count (P<0.05). Differential white cell count showed that the elevation was distributed in most cell types. Correlation matrix was done for the above systemic parameters and indices of airway inflammation including sputum volume, purulence, and polymorph count and FEV 1. There was an inverse correlation between total peripheral WBC count and FEV 1 in percentage of predicted (P<0.01), and a positive correlation between sputum purulence and sputum polymorph score (P<0.05). This suggests that host peripheral leucocyte response may be a factor in the determination of lung function.