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Article: The hepatitis C virus genome: A guide to its conserved sequences and candidate epitopes

TitleThe hepatitis C virus genome: A guide to its conserved sequences and candidate epitopes
Authors
Lin, HJLau, JYNLauder, IJShi, NLai, CHollinger, FB
KeywordsAntigenic sites
Computer algorithms
Kernel density analysis
Polymerase chain reaction
Primer design
Issue Date1993
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/virusres
Citation
Virus Research, 1993, v. 30 n. 1, p. 27-41 How to Cite?
DOI: http://dx.doi.org/10.1016/0168-1702(93)90013-D
AbstractA comprehensive analysis of reported hepatitis C virus genomic sequences comprising 151 partial or complete nucleotide sequences and 159 partial or complete amino acid sequences revealed an irregular composition of conserved and variable regions. There were but eight conserved nucleotide sequences, none outside the 5' noncoding and structural regions. A search among conserved amino acid sequences revealed 14 candidate B-cell epitopes, which were chosen mainly on the basis of their hydrophilicity profiles. Twenty five candidate T-cell epitopes were selected according to the criteria of absolute conservation of amino acid sequence, together with characteristic sequence motifs, amphipathic helical structure, or both. Conserved peptide sequences, with the characteristics of both B- and T-cell epitopes, were identified in the nonstructural 5 (NS5) region of the genome.
Persistent Identifierhttp://hdl.handle.net/10722/161986
ISSN
0168-1702
2021 Impact Factor: 6.286
2020 SCImago Journal Rankings: 1.175

 

DC FieldValueLanguage
dc.contributor.authorLin, HJen_US
dc.contributor.authorLau, JYNen_US
dc.contributor.authorLauder, IJen_US
dc.contributor.authorShi, Nen_US
dc.contributor.authorLai, Cen_US
dc.contributor.authorHollinger, FBen_US
dc.date.accessioned2012-09-05T05:16:29Z-
dc.date.available2012-09-05T05:16:29Z-
dc.date.issued1993en_US
dc.identifier.citationVirus Research, 1993, v. 30 n. 1, p. 27-41en_US
dc.identifier.issn0168-1702en_US
dc.identifier.urihttp://hdl.handle.net/10722/161986-
dc.description.abstractA comprehensive analysis of reported hepatitis C virus genomic sequences comprising 151 partial or complete nucleotide sequences and 159 partial or complete amino acid sequences revealed an irregular composition of conserved and variable regions. There were but eight conserved nucleotide sequences, none outside the 5' noncoding and structural regions. A search among conserved amino acid sequences revealed 14 candidate B-cell epitopes, which were chosen mainly on the basis of their hydrophilicity profiles. Twenty five candidate T-cell epitopes were selected according to the criteria of absolute conservation of amino acid sequence, together with characteristic sequence motifs, amphipathic helical structure, or both. Conserved peptide sequences, with the characteristics of both B- and T-cell epitopes, were identified in the nonstructural 5 (NS5) region of the genome.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/virusresen_US
dc.relation.ispartofVirus Researchen_US
dc.subjectAntigenic sites-
dc.subjectComputer algorithms-
dc.subjectKernel density analysis-
dc.subjectPolymerase chain reaction-
dc.subjectPrimer design-
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshB-Lymphocytes - Immunologyen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshConserved Sequence - Genetics - Immunologyen_US
dc.subject.meshEpitopes - Geneticsen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHepacivirus - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshT-Lymphocytes - Immunologyen_US
dc.titleThe hepatitis C virus genome: A guide to its conserved sequences and candidate epitopesen_US
dc.typeArticleen_US
dc.identifier.emailLai, C:hrmelcl@hku.hken_US
dc.identifier.authorityLai, C=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0168-1702(93)90013-Den_US
dc.identifier.pmid7505514-
dc.identifier.scopuseid_2-s2.0-0027360373en_US
dc.identifier.volume30en_US
dc.identifier.issue1en_US
dc.identifier.spage27en_US
dc.identifier.epage41en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLin, HJ=7405571292en_US
dc.identifier.scopusauthoridLau, JYN=7402446047en_US
dc.identifier.scopusauthoridLauder, IJ=35564928000en_US
dc.identifier.scopusauthoridShi, N=36640219400en_US
dc.identifier.scopusauthoridLai, C=7403086396en_US
dc.identifier.scopusauthoridHollinger, FB=7006586549en_US
dc.identifier.issnl0168-1702-

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