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Article: Structural analogs of tylophora alkaloids may not be functional analogs

TitleStructural analogs of tylophora alkaloids may not be functional analogs
Authors
Gao, WChen, APCLeung, CHGullen, EAFürstner, AShi, QWei, LLee, KHCheng, YC
KeywordsProtein, DNA, and RNA synthesis
Structure-activity relationship
Tylophora alkaloids
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl
Citation
Bioorganic And Medicinal Chemistry Letters, 2008, v. 18 n. 2, p. 704-709 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bmcl.2007.11.054
AbstractPhenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-κB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Because they do not have an identical spectrum of targets, the studied compounds are structural, but may not be functional analogs. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168271
ISSN
0960-894X
2021 Impact Factor: 2.940
2020 SCImago Journal Rankings: 0.617
ISI Accession Number ID
WOS:000253410100050
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorGao, Wen_US
dc.contributor.authorChen, APCen_US
dc.contributor.authorLeung, CHen_US
dc.contributor.authorGullen, EAen_US
dc.contributor.authorFürstner, Aen_US
dc.contributor.authorShi, Qen_US
dc.contributor.authorWei, Len_US
dc.contributor.authorLee, KHen_US
dc.contributor.authorCheng, YCen_US
dc.date.accessioned2012-10-08T03:16:54Z-
dc.date.available2012-10-08T03:16:54Z-
dc.date.issued2008en_US
dc.identifier.citationBioorganic And Medicinal Chemistry Letters, 2008, v. 18 n. 2, p. 704-709en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/168271-
dc.description.abstractPhenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-κB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Because they do not have an identical spectrum of targets, the studied compounds are structural, but may not be functional analogs. © 2007 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmclen_US
dc.relation.ispartofBioorganic and Medicinal Chemistry Lettersen_US
dc.subjectProtein, DNA, and RNA synthesis-
dc.subjectStructure-activity relationship-
dc.subjectTylophora alkaloids-
dc.subject.meshAlkaloids - Chemistry - Pharmacologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshHumansen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshTylophora - Chemistryen_US
dc.titleStructural analogs of tylophora alkaloids may not be functional analogsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_US
dc.identifier.authorityLeung, CH=rp00730en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bmcl.2007.11.054en_US
dc.identifier.pmid18077159-
dc.identifier.scopuseid_2-s2.0-38349057944en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38349057944&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.spage704en_US
dc.identifier.epage709en_US
dc.identifier.isiWOS:000253410100050-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGao, W=7402758247en_US
dc.identifier.scopusauthoridChen, APC=36984992200en_US
dc.identifier.scopusauthoridLeung, CH=7402612570en_US
dc.identifier.scopusauthoridGullen, EA=6602138704en_US
dc.identifier.scopusauthoridFürstner, A=7006374153en_US
dc.identifier.scopusauthoridShi, Q=7402698456en_US
dc.identifier.scopusauthoridWei, L=35075256300en_US
dc.identifier.scopusauthoridLee, KH=35450969800en_US
dc.identifier.scopusauthoridCheng, YC=36041844200en_US
dc.identifier.issnl0960-894X-

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