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Conference Paper: Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration

TitleComparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migration
Authors
Li, GZhang, XAWang, HWang, XMeng, CLChan, CYYew, DTWTsang, KSLi, KTsai, SNNgai, SMHan, ZCLin, MCMHe, MLKung, HF
Issue Date2011
Citation
Advances In Experimental Medicine And Biology, 2011, v. 720, p. 51-68 How to Cite?
DOI: http://dx.doi.org/10.1007/978-1-4614-0254-1_5
AbstractUmbilical cord (UC) and placenta (P) have been suggested as alternatives to bone marrow (BM) as sources of mesenchymal stem cells (MSC) for cell therapy, with both UC- and P-MSC possess immunophenotypic and functional characteristics similar to BM-MSC. However, under defined conditions, the migration capacity of BM- and P-MSC was found to be 5.9- and 3.2-folds higher than that of UC-MSC, respectively. By the use of 2-DE and combined MS and MS/MS analysis, six differentially expressed proteins were identified among these MSC samples, with five of them known to be involved in cell migration as migration enhancing or inhibiting proteins. Interestingly, the expression levels of those proteins reflect perfectly the migration capacity of corresponding MSC, which is also proved by in vitro overexpression and silencing techniques. Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC. © 2011 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/168877
ISSN
0065-2598
2021 Impact Factor: 3.650
2020 SCImago Journal Rankings: 0.529
ISI Accession Number ID
WOS:000339175100019
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, Gen_US
dc.contributor.authorZhang, XAen_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorMeng, CLen_US
dc.contributor.authorChan, CYen_US
dc.contributor.authorYew, DTWen_US
dc.contributor.authorTsang, KSen_US
dc.contributor.authorLi, Ken_US
dc.contributor.authorTsai, SNen_US
dc.contributor.authorNgai, SMen_US
dc.contributor.authorHan, ZCen_US
dc.contributor.authorLin, MCMen_US
dc.contributor.authorHe, MLen_US
dc.contributor.authorKung, HFen_US
dc.date.accessioned2012-10-08T03:35:22Z-
dc.date.available2012-10-08T03:35:22Z-
dc.date.issued2011en_US
dc.identifier.citationAdvances In Experimental Medicine And Biology, 2011, v. 720, p. 51-68en_US
dc.identifier.issn0065-2598en_US
dc.identifier.urihttp://hdl.handle.net/10722/168877-
dc.description.abstractUmbilical cord (UC) and placenta (P) have been suggested as alternatives to bone marrow (BM) as sources of mesenchymal stem cells (MSC) for cell therapy, with both UC- and P-MSC possess immunophenotypic and functional characteristics similar to BM-MSC. However, under defined conditions, the migration capacity of BM- and P-MSC was found to be 5.9- and 3.2-folds higher than that of UC-MSC, respectively. By the use of 2-DE and combined MS and MS/MS analysis, six differentially expressed proteins were identified among these MSC samples, with five of them known to be involved in cell migration as migration enhancing or inhibiting proteins. Interestingly, the expression levels of those proteins reflect perfectly the migration capacity of corresponding MSC, which is also proved by in vitro overexpression and silencing techniques. Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC. © 2011 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.relation.ispartofAdvances in Experimental Medicine and Biologyen_US
dc.titleComparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: Implication in the migrationen_US
dc.typeConference_Paperen_US
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MCM=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/978-1-4614-0254-1_5en_US
dc.identifier.pmid23740023-
dc.identifier.scopuseid_2-s2.0-80053910493en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053910493&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume720en_US
dc.identifier.spage51en_US
dc.identifier.epage68en_US
dc.identifier.isiWOS:000339175100019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, G=7407055832en_US
dc.identifier.scopusauthoridZhang, XA=53986855400en_US
dc.identifier.scopusauthoridWang, H=7501747965en_US
dc.identifier.scopusauthoridWang, X=35235704600en_US
dc.identifier.scopusauthoridMeng, CL=36927269600en_US
dc.identifier.scopusauthoridChan, CY=22033276600en_US
dc.identifier.scopusauthoridYew, DTW=7007034694en_US
dc.identifier.scopusauthoridTsang, KS=7201555004en_US
dc.identifier.scopusauthoridLi, K=7404990071en_US
dc.identifier.scopusauthoridTsai, SN=8707094300en_US
dc.identifier.scopusauthoridNgai, SM=7006074219en_US
dc.identifier.scopusauthoridHan, ZC=7402859036en_US
dc.identifier.scopusauthoridLin, MCM=7404816359en_US
dc.identifier.scopusauthoridHe, ML=35080389700en_US
dc.identifier.scopusauthoridKung, HF=7402514190en_US
dc.identifier.issnl0065-2598-

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