File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.biomaterials.2003.09.077
- Scopus: eid_2-s2.0-1142309722
- PMID: 14967533
- WOS: WOS:000189221600012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: A rapid temperature-responsive sol-gel reversible poly(N- isopropylacrylamide)-g-methylcellulose copolymer hydrogel
Title | A rapid temperature-responsive sol-gel reversible poly(N- isopropylacrylamide)-g-methylcellulose copolymer hydrogel |
---|---|
Authors | |
Keywords | Hydrogel Methylcellulose Poly(N-isopropylacrylamide) Temperature responsive |
Issue Date | 2004 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials |
Citation | Biomaterials, 2004, v. 25 n. 15, p. 3005-3012 How to Cite? |
Abstract | Poly(N-isopropylacrylamide) (PNIPAAm) was grafted to methylcellulose (MC) with various feeding ratios using ammonium persulfate and N,N,N′,N′- tetramethyl ethylene diamine as an initiator. FTIR results confirm the formation of PNIPAAm-g-MC copolymers. The temperature responsiveness of copolymer gels was investigated by turbidimetry, dynamic contact angle (DCA), differential scanning calorimetry and dynamic mechanical analysis (DMA). The results indicate that PNIPAAm-g-MC hydrogels are strongly temperature responsive. At lower contents of MC, the lower critical solution temperature (LCST) is decreased, whereas further increasing MC contents raises the LCSTs. It is observed that the phase transition of the hydrogels occurs reversibly within 1min, and near body temperature, a rigid gel can be generated in a certain range of MC content. What is more, the incorporation of MC prevents the syneresis of copolymer hydrogel. DMA measurement reveals that the storage moduli (E′) of the gels increase upon increasing MC contents, and moreover the values of E′ go up markedly above LCST. The copolymer hydrogels hold a promise as a blood vessel barrier by tuning gelation temperature, gelation time and mechanical strength. © 2003 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/170060 |
ISSN | 2021 Impact Factor: 15.304 2020 SCImago Journal Rankings: 3.209 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, W | en_US |
dc.contributor.author | Zhang, B | en_US |
dc.contributor.author | Lu, WW | en_US |
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Zhu, D | en_US |
dc.contributor.author | Yao, KD | en_US |
dc.contributor.author | Wang, Q | en_US |
dc.contributor.author | Zhao, C | en_US |
dc.contributor.author | Wang, C | en_US |
dc.date.accessioned | 2012-10-30T06:05:04Z | - |
dc.date.available | 2012-10-30T06:05:04Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Biomaterials, 2004, v. 25 n. 15, p. 3005-3012 | en_US |
dc.identifier.issn | 0142-9612 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170060 | - |
dc.description.abstract | Poly(N-isopropylacrylamide) (PNIPAAm) was grafted to methylcellulose (MC) with various feeding ratios using ammonium persulfate and N,N,N′,N′- tetramethyl ethylene diamine as an initiator. FTIR results confirm the formation of PNIPAAm-g-MC copolymers. The temperature responsiveness of copolymer gels was investigated by turbidimetry, dynamic contact angle (DCA), differential scanning calorimetry and dynamic mechanical analysis (DMA). The results indicate that PNIPAAm-g-MC hydrogels are strongly temperature responsive. At lower contents of MC, the lower critical solution temperature (LCST) is decreased, whereas further increasing MC contents raises the LCSTs. It is observed that the phase transition of the hydrogels occurs reversibly within 1min, and near body temperature, a rigid gel can be generated in a certain range of MC content. What is more, the incorporation of MC prevents the syneresis of copolymer hydrogel. DMA measurement reveals that the storage moduli (E′) of the gels increase upon increasing MC contents, and moreover the values of E′ go up markedly above LCST. The copolymer hydrogels hold a promise as a blood vessel barrier by tuning gelation temperature, gelation time and mechanical strength. © 2003 Elsevier Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials | en_US |
dc.relation.ispartof | Biomaterials | en_US |
dc.subject | Hydrogel | - |
dc.subject | Methylcellulose | - |
dc.subject | Poly(N-isopropylacrylamide) | - |
dc.subject | Temperature responsive | - |
dc.subject.mesh | Acrylic Resins - Chemistry | en_US |
dc.subject.mesh | Biocompatible Materials - Chemistry | en_US |
dc.subject.mesh | Elasticity | en_US |
dc.subject.mesh | Hot Temperature | en_US |
dc.subject.mesh | Hydrogels - Chemistry | en_US |
dc.subject.mesh | Macromolecular Substances | en_US |
dc.subject.mesh | Materials Testing | en_US |
dc.subject.mesh | Methylcellulose - Chemistry | en_US |
dc.subject.mesh | Molecular Conformation | en_US |
dc.subject.mesh | Phase Transition | en_US |
dc.subject.mesh | Polymers | en_US |
dc.subject.mesh | Surface Properties | en_US |
dc.subject.mesh | Temperature | en_US |
dc.subject.mesh | Transition Temperature | en_US |
dc.subject.mesh | Viscosity | en_US |
dc.title | A rapid temperature-responsive sol-gel reversible poly(N- isopropylacrylamide)-g-methylcellulose copolymer hydrogel | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lu, WW:wwlu@hku.hk | en_US |
dc.identifier.authority | Lu, WW=rp00411 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.biomaterials.2003.09.077 | en_US |
dc.identifier.pmid | 14967533 | - |
dc.identifier.scopus | eid_2-s2.0-1142309722 | en_US |
dc.identifier.hkuros | 87294 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-1142309722&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 15 | en_US |
dc.identifier.spage | 3005 | en_US |
dc.identifier.epage | 3012 | en_US |
dc.identifier.isi | WOS:000189221600012 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Liu, W=7408473555 | en_US |
dc.identifier.scopusauthorid | Zhang, B=8512129100 | en_US |
dc.identifier.scopusauthorid | Lu, WW=7404215221 | en_US |
dc.identifier.scopusauthorid | Li, X=15219864000 | en_US |
dc.identifier.scopusauthorid | Zhu, D=7403598606 | en_US |
dc.identifier.scopusauthorid | Yao, KD=7403234424 | en_US |
dc.identifier.scopusauthorid | Wang, Q=8841951000 | en_US |
dc.identifier.scopusauthorid | Zhao, C=12142770900 | en_US |
dc.identifier.scopusauthorid | Wang, C=12799878700 | en_US |
dc.identifier.issnl | 0142-9612 | - |