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Article: The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study
Title | The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study |
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Authors | |
Keywords | Body height Body mass Body weight Clinical assessment Disease severity |
Issue Date | 2012 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/ |
Citation | Arthritis & Rheumatism, 2012, v. 64 n. 5, p. 1488-1496 How to Cite? |
Abstract | Objective To investigate the association of being overweight or obese with the presence, extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in adults. Methods A population-based cross-sectional study of 2,599 southern Chinese volunteers was conducted. Subjects underwent radiographic and clinical assessment, and weight and height were measured. Sagittal T2-weighted MRIs of the lumbar spine were obtained. The presence, extent, and severity of disc degeneration and additional radiographic and clinical parameters were assessed. Asian-modified body mass index (BMI) (kg/m 2) categories were used. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results The study included 1,040 men and 1,559 women (mean age 41.9 years). Disc degeneration was noted in 1,890 subjects (72.7%). BMI was significantly higher in subjects with disc degeneration (mean 23.3 kg/m 2) than in subjects without degeneration (mean 21.7 kg/m 2) (P < 0.001). A significant increase in the number of degenerated levels (P < 0.001), global severity of disc degeneration (P < 0.001), and end-stage disc degeneration with disc space narrowing (P < 0.001) was noted with elevated BMI, in particular in overweight and obese subjects. In the adjusted multivariate logistic regression model, there was a positive linear trend (r 2 = 0.99) between BMI and the overall presence of disc degeneration in overweight (OR 1.30 [95% CI 1.03-1.62]) and obese (OR 1.79 [95% CI 1.17-2.74]) subjects. End-stage disc degeneration with disc space narrowing was significantly more pronounced in obese subjects (adjusted OR 1.72 [95% CI 1.23-2.41] [reference normal weight]). Conclusion Our findings, in one of the largest studies to systematically assess lumbar disc degeneration on MRI, indicated a significant association between the presence, extent, and global severity of disc degeneration with weight in overweight and obese adults. Copyright © 2012 by the American College of Rheumatology. |
Persistent Identifier | http://hdl.handle.net/10722/170197 |
ISSN | 2015 Impact Factor: 8.955 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Samartzis, D | en_US |
dc.contributor.author | Karppinen, J | en_US |
dc.contributor.author | Chan, D | en_US |
dc.contributor.author | Luk, KDK | en_US |
dc.contributor.author | Cheung, KMC | en_US |
dc.date.accessioned | 2012-10-30T06:06:06Z | - |
dc.date.available | 2012-10-30T06:06:06Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Arthritis & Rheumatism, 2012, v. 64 n. 5, p. 1488-1496 | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170197 | - |
dc.description.abstract | Objective To investigate the association of being overweight or obese with the presence, extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in adults. Methods A population-based cross-sectional study of 2,599 southern Chinese volunteers was conducted. Subjects underwent radiographic and clinical assessment, and weight and height were measured. Sagittal T2-weighted MRIs of the lumbar spine were obtained. The presence, extent, and severity of disc degeneration and additional radiographic and clinical parameters were assessed. Asian-modified body mass index (BMI) (kg/m 2) categories were used. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results The study included 1,040 men and 1,559 women (mean age 41.9 years). Disc degeneration was noted in 1,890 subjects (72.7%). BMI was significantly higher in subjects with disc degeneration (mean 23.3 kg/m 2) than in subjects without degeneration (mean 21.7 kg/m 2) (P < 0.001). A significant increase in the number of degenerated levels (P < 0.001), global severity of disc degeneration (P < 0.001), and end-stage disc degeneration with disc space narrowing (P < 0.001) was noted with elevated BMI, in particular in overweight and obese subjects. In the adjusted multivariate logistic regression model, there was a positive linear trend (r 2 = 0.99) between BMI and the overall presence of disc degeneration in overweight (OR 1.30 [95% CI 1.03-1.62]) and obese (OR 1.79 [95% CI 1.17-2.74]) subjects. End-stage disc degeneration with disc space narrowing was significantly more pronounced in obese subjects (adjusted OR 1.72 [95% CI 1.23-2.41] [reference normal weight]). Conclusion Our findings, in one of the largest studies to systematically assess lumbar disc degeneration on MRI, indicated a significant association between the presence, extent, and global severity of disc degeneration with weight in overweight and obese adults. Copyright © 2012 by the American College of Rheumatology. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/ | en_US |
dc.relation.ispartof | Arthritis & Rheumatism | en_US |
dc.rights | Arthritis & Rheumatism. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Body height | - |
dc.subject | Body mass | - |
dc.subject | Body weight | - |
dc.subject | Clinical assessment | - |
dc.subject | Disease severity | - |
dc.subject.mesh | Young adult | en_US |
dc.subject.mesh | Population surveillance | en_US |
dc.subject.mesh | Overweight - Epidemiology - Pathology | en_US |
dc.subject.mesh | Obesity - Epidemiology - Pathology | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Magnetic resonance imaging - Methods | en_US |
dc.subject.mesh | Lumbar vertebrae - Pathology | en_US |
dc.subject.mesh | Intervertebral disc degeneration - Epidemiology - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hong Kong - Epidemiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Comorbidity | en_US |
dc.subject.mesh | Body mass index | en_US |
dc.subject.mesh | Adult | en_US |
dc.title | The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study | en_US |
dc.type | Article | en_US |
dc.identifier.email | Samartzis, D: dspine@hku.hk | en_US |
dc.identifier.email | Chan, D: chand@hku.hk | en_US |
dc.identifier.email | Luk, KDK: hcm21000@hku.hk | en_US |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.authority | Samartzis, D=rp01430 | en_US |
dc.identifier.authority | Chan, D=rp00540 | en_US |
dc.identifier.authority | Luk, KDK=rp00333 | en_US |
dc.identifier.authority | Cheung, KMC=rp00387 | - |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/art.33462 | en_US |
dc.identifier.pmid | 22287295 | - |
dc.identifier.scopus | eid_2-s2.0-84860442850 | en_US |
dc.identifier.hkuros | 208412 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84860442850&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 1488 | en_US |
dc.identifier.epage | 1496 | en_US |
dc.identifier.eissn | 1529-0131 | - |
dc.identifier.isi | WOS:000303239000025 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Cheung, KMC=7402406754 | en_US |
dc.identifier.scopusauthorid | Luk, KDK=55171413200 | en_US |
dc.identifier.scopusauthorid | Chan, D=7402216545 | en_US |
dc.identifier.scopusauthorid | Karppinen, J=7004560479 | en_US |
dc.identifier.scopusauthorid | Samartzis, D=34572771100 | en_US |
dc.identifier.issnl | 0004-3591 | - |