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- Scopus: eid_2-s2.0-0023137661
- PMID: 3027313
- WOS: WOS:A1987G081700019
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Article: Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17β-estradiol
Title | Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17β-estradiol |
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Authors | |
Issue Date | 1987 |
Publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org |
Citation | Journal Of Pharmacology And Experimental Therapeutics, 1987, v. 240 n. 2, p. 466-470 How to Cite? |
Abstract | Experiments were designed to determine the effect of estrogen pretreatment on alpha adrenergic responsiveness of blood vessels of the rabbit. Rabbits were ovariectomized and, after 8 days of recovery, treated with 17β-estradiol (100 μg i.m.; estrogen group) or solvent (control group) for 4 days. Rings of saphenous vein and femoral artery (both without endothelium) were mounted for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution (37°C), gassed with 95% O2-5% CO2. All experiments were performed in the presence of inhibitors of neuronal uptake, extraneuronal uptake and beta adrenoceptors. In the saphenous vein, the estrogen treatment did not significantly affect the concentration-effect curves evoked by norepinephrine (either under control conditions or after alpha-1 or alpha-2 adrenergic blockade), phenylephrine (an alpha-1 adrenergic agonist) or UK 14,304 (an alpha-2 adrenergic agonist). In the femoral artery, estrogen treatment depressed the contractile responses evoked by norepinephrine (under control conditions) but not those produced by phenylephrine; UK 14,304 did not evoke a contractile response. The depressant effect of estrogen treatment on the concentration-effect curve to norepinephrine in the femoral artery was prevented by the alpha-2 adrenergic antagonist, rauwolscine. The results in the femoral artery but not in the saphenous vein suggest that estrogens depress alpha-2 but not alpha-1 adrenergic responsiveness. In the femoral artery, alpha-2 adrenoceptor stimulation does not cause contraction per se but apparently can facilitate alpha-1 adrenergic responses. This probably results from a reduced density of alpha-2 adrenoceptors in this blood vessel. Thus, the inhibitory influence of estrogen on alpha adrenergic responses of vascular smooth muscle may depend on the density of adrenoceptors (or spare receptors). |
Persistent Identifier | http://hdl.handle.net/10722/170841 |
ISSN | 2021 Impact Factor: 4.402 2020 SCImago Journal Rankings: 1.286 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gisclard, V | en_US |
dc.contributor.author | Flavahan, NA | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:04Z | - |
dc.date.available | 2012-10-30T06:11:04Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Journal Of Pharmacology And Experimental Therapeutics, 1987, v. 240 n. 2, p. 466-470 | en_US |
dc.identifier.issn | 0022-3565 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170841 | - |
dc.description.abstract | Experiments were designed to determine the effect of estrogen pretreatment on alpha adrenergic responsiveness of blood vessels of the rabbit. Rabbits were ovariectomized and, after 8 days of recovery, treated with 17β-estradiol (100 μg i.m.; estrogen group) or solvent (control group) for 4 days. Rings of saphenous vein and femoral artery (both without endothelium) were mounted for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution (37°C), gassed with 95% O2-5% CO2. All experiments were performed in the presence of inhibitors of neuronal uptake, extraneuronal uptake and beta adrenoceptors. In the saphenous vein, the estrogen treatment did not significantly affect the concentration-effect curves evoked by norepinephrine (either under control conditions or after alpha-1 or alpha-2 adrenergic blockade), phenylephrine (an alpha-1 adrenergic agonist) or UK 14,304 (an alpha-2 adrenergic agonist). In the femoral artery, estrogen treatment depressed the contractile responses evoked by norepinephrine (under control conditions) but not those produced by phenylephrine; UK 14,304 did not evoke a contractile response. The depressant effect of estrogen treatment on the concentration-effect curve to norepinephrine in the femoral artery was prevented by the alpha-2 adrenergic antagonist, rauwolscine. The results in the femoral artery but not in the saphenous vein suggest that estrogens depress alpha-2 but not alpha-1 adrenergic responsiveness. In the femoral artery, alpha-2 adrenoceptor stimulation does not cause contraction per se but apparently can facilitate alpha-1 adrenergic responses. This probably results from a reduced density of alpha-2 adrenoceptors in this blood vessel. Thus, the inhibitory influence of estrogen on alpha adrenergic responses of vascular smooth muscle may depend on the density of adrenoceptors (or spare receptors). | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org | en_US |
dc.relation.ispartof | Journal of Pharmacology and Experimental Therapeutics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Vessels - Physiology | en_US |
dc.subject.mesh | Estradiol - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Ovariectomy | en_US |
dc.subject.mesh | Phenylephrine - Pharmacology | en_US |
dc.subject.mesh | Prazosin - Pharmacology | en_US |
dc.subject.mesh | Quinoxalines - Pharmacology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Drug Effects | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects | en_US |
dc.subject.mesh | Vasomotor System - Drug Effects | en_US |
dc.subject.mesh | Yohimbine - Pharmacology | en_US |
dc.title | Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17β-estradiol | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3027313 | - |
dc.identifier.scopus | eid_2-s2.0-0023137661 | en_US |
dc.identifier.volume | 240 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 466 | en_US |
dc.identifier.epage | 470 | en_US |
dc.identifier.isi | WOS:A1987G081700019 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Gisclard, V=6505914966 | en_US |
dc.identifier.scopusauthorid | Flavahan, NA=7006398882 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0022-3565 | - |