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Article: The antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats

TitleThe antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats
Authors
Koo, MWLCho, CHOgle, CW
KeywordsCalcium
Calcium gluconate
EGTA
Stress ulceration
Verapamil
Issue Date1989
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 1989, v. 34 n. 1, p. 73-76 How to Cite?
DOI: http://dx.doi.org/10.1016/0091-3057(89)90355-9
AbstractThe antiulcer effect of verapamil, and its relationship to stomach calcium levels, were examined in rats restrained at 4°C (stress). Stress for 2 hr significantly increased muscle calcium and induced mucosal ulceration in the gastric glandular segment; calcium concentrations in the glandular mucosa and serum were unaffected. Verapamil or calcium gluconate given 30 min before stress prevented the rise in gastric muscle calcium, and attenuated ulcer severity. Bis(β-aminoethylether)-NNN'N'-tetra-acetic acid (EGTA) pretreatment, however, further elevated stomach muscle calcium and markedly worsened lesion formation. These findings suggest that increased stomach muscle calcium could be a causal factor in stress-induced gastric glandular ulceration.
Persistent Identifierhttp://hdl.handle.net/10722/170926
ISSN
0091-3057
2021 Impact Factor: 3.697
2020 SCImago Journal Rankings: 1.184
ISI Accession Number ID
WOS:A1989AZ59700013

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorOgle, CWen_US
dc.date.accessioned2012-10-30T06:11:27Z-
dc.date.available2012-10-30T06:11:27Z-
dc.date.issued1989en_US
dc.identifier.citationPharmacology Biochemistry And Behavior, 1989, v. 34 n. 1, p. 73-76en_US
dc.identifier.issn0091-3057en_US
dc.identifier.urihttp://hdl.handle.net/10722/170926-
dc.description.abstractThe antiulcer effect of verapamil, and its relationship to stomach calcium levels, were examined in rats restrained at 4°C (stress). Stress for 2 hr significantly increased muscle calcium and induced mucosal ulceration in the gastric glandular segment; calcium concentrations in the glandular mucosa and serum were unaffected. Verapamil or calcium gluconate given 30 min before stress prevented the rise in gastric muscle calcium, and attenuated ulcer severity. Bis(β-aminoethylether)-NNN'N'-tetra-acetic acid (EGTA) pretreatment, however, further elevated stomach muscle calcium and markedly worsened lesion formation. These findings suggest that increased stomach muscle calcium could be a causal factor in stress-induced gastric glandular ulceration.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.subjectCalcium-
dc.subjectCalcium gluconate-
dc.subjectEGTA-
dc.subjectStress ulceration-
dc.subjectVerapamil-
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Analysis - Blooden_US
dc.subject.meshCalcium Gluconate - Administration & Dosage - Pharmacology - Therapeutic Useen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEgtazic Acid - Administration & Dosage - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshRestraint, Physicalen_US
dc.subject.meshStomach - Analysisen_US
dc.subject.meshStomach Ulcer - Prevention & Controlen_US
dc.subject.meshStress, Physiological - Metabolismen_US
dc.subject.meshVerapamil - Administration & Dosage - Pharmacology - Therapeutic Useen_US
dc.titleThe antiulcer effect of verapamil in relation to gastric calcium levels in stressed ratsen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0091-3057(89)90355-9en_US
dc.identifier.pmid2516633-
dc.identifier.scopuseid_2-s2.0-0024377247en_US
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.spage73en_US
dc.identifier.epage76en_US
dc.identifier.isiWOS:A1989AZ59700013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridCho, CH=14067000400en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US
dc.identifier.issnl0091-3057-

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