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Article: Interaction of tertatolol at the 'atypical' or beta3-adrenoceptor in guinea-pig ileum

TitleInteraction of tertatolol at the 'atypical' or beta3-adrenoceptor in guinea-pig ileum
Authors
Bond, RAVanhoutte, PM
Issue Date1992
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1992, v. 23 n. 2, p. 171-176 How to Cite?
DOI: http://dx.doi.org/10.1016/0306-3623(92)90005-5
AbstractExperiments were performed to investigate the possible interaction between tertatolol and the 'atypical' beta-adrenoceptor present in guinea-pig ileum. In the electrically field stimulated guinea-pig ileum, both isoprenaline and BRL-37344 produce concentration-dependent inhibition of the 'twitch' response. Schild regression analysis of the interaction between isoprenaline and tertatolol indicated two sites of action and yielded an apoparent pA2 value for tertatolol of 6.8 at the 'atypical' beta-adrenoceptor. BRL-37344 selectively activated the 'atypical' beta-adrenoceptor and tertatolol again yielded an apparent pA2 value of 6.7 and 6.8.
Persistent Identifierhttp://hdl.handle.net/10722/171053
ISSN
0306-3623
ISI Accession Number ID
WOS:A1992HF71500005

 

DC FieldValueLanguage
dc.contributor.authorBond, RAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:00Z-
dc.date.available2012-10-30T06:12:00Z-
dc.date.issued1992en_US
dc.identifier.citationGeneral Pharmacology, 1992, v. 23 n. 2, p. 171-176en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/171053-
dc.description.abstractExperiments were performed to investigate the possible interaction between tertatolol and the 'atypical' beta-adrenoceptor present in guinea-pig ileum. In the electrically field stimulated guinea-pig ileum, both isoprenaline and BRL-37344 produce concentration-dependent inhibition of the 'twitch' response. Schild regression analysis of the interaction between isoprenaline and tertatolol indicated two sites of action and yielded an apoparent pA2 value for tertatolol of 6.8 at the 'atypical' beta-adrenoceptor. BRL-37344 selectively activated the 'atypical' beta-adrenoceptor and tertatolol again yielded an apparent pA2 value of 6.7 and 6.8.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAdrenergic Beta-Agonists - Pharmacologyen_US
dc.subject.meshAdrenergic Beta-Antagonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshEthanolamines - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIleum - Drug Effectsen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethiothepin - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effectsen_US
dc.subject.meshPropanolamines - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Beta - Drug Effectsen_US
dc.subject.meshThiophenesen_US
dc.titleInteraction of tertatolol at the 'atypical' or beta3-adrenoceptor in guinea-pig ileumen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(92)90005-5-
dc.identifier.pmid1353468-
dc.identifier.scopuseid_2-s2.0-0026573537en_US
dc.identifier.volume23en_US
dc.identifier.issue2en_US
dc.identifier.spage171en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:A1992HF71500005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBond, RA=7102696356en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0306-3623-

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