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Article: Human colostral cells: Phagocytosis and killing of E. coli and C. albicans

TitleHuman colostral cells: Phagocytosis and killing of E. coli and C. albicans
Authors
Ho, PCLawton, JWM
Issue Date1978
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpeds
Citation
Journal Of Pediatrics, 1978, v. 93 n. 6, p. 910-915 How to Cite?
DOI: http://dx.doi.org/10.1016/S0022-3476(78)81210-4
AbstractCells from human colostrum, collected from mothers within 48 hrs of delivery, were examined for their capacity to phagocytose and kill E. coli and Candida albicans. The phagocytic power of colostral cells was comparable to that of blood leukocytes from the same individuals. In contrast, the capacity of colostral cells to kill microorganisms was significantly less than that of blood leukocytes. Preincubation of blood leukocytes with colostrum supernatant did not reduce phagocytic indices, but reduced E. coli killing by 40% and C. albicans killing by 66%. The role of colostral cells in protecting the neonate from infection is discussed in the light of these findings.
Persistent Identifierhttp://hdl.handle.net/10722/173053
ISSN
0022-3476
2021 Impact Factor: 6.314
2020 SCImago Journal Rankings: 1.227
ISI Accession Number ID
WOS:A1978FX83100002

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorLawton, JWMen_US
dc.date.accessioned2012-10-30T06:27:42Z-
dc.date.available2012-10-30T06:27:42Z-
dc.date.issued1978en_US
dc.identifier.citationJournal Of Pediatrics, 1978, v. 93 n. 6, p. 910-915en_US
dc.identifier.issn0022-3476en_US
dc.identifier.urihttp://hdl.handle.net/10722/173053-
dc.description.abstractCells from human colostrum, collected from mothers within 48 hrs of delivery, were examined for their capacity to phagocytose and kill E. coli and Candida albicans. The phagocytic power of colostral cells was comparable to that of blood leukocytes from the same individuals. In contrast, the capacity of colostral cells to kill microorganisms was significantly less than that of blood leukocytes. Preincubation of blood leukocytes with colostrum supernatant did not reduce phagocytic indices, but reduced E. coli killing by 40% and C. albicans killing by 66%. The role of colostral cells in protecting the neonate from infection is discussed in the light of these findings.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpedsen_US
dc.relation.ispartofJournal of Pediatricsen_US
dc.subject.meshBacterial Infections - Prevention & Controlen_US
dc.subject.meshBlood Bactericidal Activityen_US
dc.subject.meshBlood Cell Counten_US
dc.subject.meshCandida Albicansen_US
dc.subject.meshCell Counten_US
dc.subject.meshColostrum - Cytologyen_US
dc.subject.meshEscherichia Colien_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfant, Newborn, Diseases - Prevention & Controlen_US
dc.subject.meshLeukocytes - Physiologyen_US
dc.subject.meshLymphocytes - Physiologyen_US
dc.subject.meshNeutrophils - Physiologyen_US
dc.subject.meshPhagocytes - Physiologyen_US
dc.subject.meshPhagocytosisen_US
dc.subject.meshPregnancyen_US
dc.titleHuman colostral cells: Phagocytosis and killing of E. coli and C. albicansen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0022-3476(78)81210-4-
dc.identifier.pmid363993-
dc.identifier.scopuseid_2-s2.0-0018166196en_US
dc.identifier.volume93en_US
dc.identifier.issue6en_US
dc.identifier.spage910en_US
dc.identifier.epage915en_US
dc.identifier.isiWOS:A1978FX83100002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridLawton, JWM=7102180792en_US
dc.identifier.issnl0022-3476-

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