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- Publisher Website: 10.1093/humrep/15.10.2205
- Scopus: eid_2-s2.0-0033772390
- PMID: 11006200
- WOS: WOS:000089721400028
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Article: Randomized comparison of vaginal (200 μg every 3 h) and oral (400 μg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy
Title | Randomized comparison of vaginal (200 μg every 3 h) and oral (400 μg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy |
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Authors | |
Keywords | Mifepristone Misoprostol Second trimester abortion |
Issue Date | 2000 |
Publisher | Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/ |
Citation | Human Reproduction, 2000, v. 15 n. 10, p. 2205-2208 How to Cite? |
Abstract | It is known that when misoprostol is given at 200 μg every 3 h after mifepristone pretreatment, the vaginal route is more effective than the oral route. However, women prefer the oral route. This randomized study was to test our hypothesis that oral misoprostol 400 μg is as effective as vaginal misoprostol 200 μg when given every 3 h in termination of second trimester pregnancy after priming with mifepristone. A total of 142 patients was randomly assigned to group 1 (200 mg mifepristone + 400 μg oral misoprostol every 3 h up to five doses) or group 2 (200 mg mifepristone + 200 μg vaginal misoprostol every 3 h up to five doses). The incidence of side-effects and the preference study were assessed through a standardized questionnaire during and after the abortion. For the oral group, both the incidence of diarrhoea (40.0 versus 23.2%, P = 0.03) and the amount of drug used (1734 compared with 812 μg, P < 0.0001) were significantly higher than that of the vaginal group but the incidence of fever appeared to be lower (not significant). There was no significant difference in complete abortion rate: 81.4% in the oral group and 75.4% in the vaginal group. The median induction-abortion interval was similar in the two groups (10.4 versus 10.0 h). The percentage of women who aborted in 24 h was also similar: 57/70 (81.4%) in the oral group and 58/69 (87.0%) in the vaginal group. Overall, 82.0% of women preferred the oral route. Oral misoprostol (400 μg) given every 3 h up to five doses, when combined with mifepristone, was as effective as the vaginal (200 μg) route in second trimester termination of pregnancy. This regimen could also be offered to those women who found repeated vaginal administration unacceptable. |
Persistent Identifier | http://hdl.handle.net/10722/173237 |
ISSN | 2021 Impact Factor: 6.353 2020 SCImago Journal Rankings: 2.446 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ngai, SW | en_US |
dc.contributor.author | Tang, OS | en_US |
dc.contributor.author | Ho, PC | en_US |
dc.date.accessioned | 2012-10-30T06:28:42Z | - |
dc.date.available | 2012-10-30T06:28:42Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Human Reproduction, 2000, v. 15 n. 10, p. 2205-2208 | en_US |
dc.identifier.issn | 0268-1161 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173237 | - |
dc.description.abstract | It is known that when misoprostol is given at 200 μg every 3 h after mifepristone pretreatment, the vaginal route is more effective than the oral route. However, women prefer the oral route. This randomized study was to test our hypothesis that oral misoprostol 400 μg is as effective as vaginal misoprostol 200 μg when given every 3 h in termination of second trimester pregnancy after priming with mifepristone. A total of 142 patients was randomly assigned to group 1 (200 mg mifepristone + 400 μg oral misoprostol every 3 h up to five doses) or group 2 (200 mg mifepristone + 200 μg vaginal misoprostol every 3 h up to five doses). The incidence of side-effects and the preference study were assessed through a standardized questionnaire during and after the abortion. For the oral group, both the incidence of diarrhoea (40.0 versus 23.2%, P = 0.03) and the amount of drug used (1734 compared with 812 μg, P < 0.0001) were significantly higher than that of the vaginal group but the incidence of fever appeared to be lower (not significant). There was no significant difference in complete abortion rate: 81.4% in the oral group and 75.4% in the vaginal group. The median induction-abortion interval was similar in the two groups (10.4 versus 10.0 h). The percentage of women who aborted in 24 h was also similar: 57/70 (81.4%) in the oral group and 58/69 (87.0%) in the vaginal group. Overall, 82.0% of women preferred the oral route. Oral misoprostol (400 μg) given every 3 h up to five doses, when combined with mifepristone, was as effective as the vaginal (200 μg) route in second trimester termination of pregnancy. This regimen could also be offered to those women who found repeated vaginal administration unacceptable. | en_US |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/ | en_US |
dc.relation.ispartof | Human Reproduction | en_US |
dc.rights | Human Reproduction. Copyright © Oxford University Press. | - |
dc.subject | Mifepristone | - |
dc.subject | Misoprostol | - |
dc.subject | Second trimester abortion | - |
dc.subject.mesh | Abortifacient Agents, Nonsteroidal - Administration & Dosage - Adverse Effects | en_US |
dc.subject.mesh | Abortifacient Agents, Steroidal - Pharmacology | en_US |
dc.subject.mesh | Abortion, Induced - Methods | en_US |
dc.subject.mesh | Administration, Intravaginal | en_US |
dc.subject.mesh | Administration, Oral | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Diarrhea - Chemically Induced | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Mifepristone - Pharmacology | en_US |
dc.subject.mesh | Misoprostol - Administration & Dosage - Adverse Effects | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Trimester, Second | en_US |
dc.title | Randomized comparison of vaginal (200 μg every 3 h) and oral (400 μg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ho, PC:pcho@hku.hk | en_US |
dc.identifier.authority | Ho, PC=rp00325 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/humrep/15.10.2205 | - |
dc.identifier.pmid | 11006200 | - |
dc.identifier.scopus | eid_2-s2.0-0033772390 | en_US |
dc.identifier.hkuros | 56149 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033772390&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.spage | 2205 | en_US |
dc.identifier.epage | 2208 | en_US |
dc.identifier.isi | WOS:000089721400028 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Ngai, SW=7006074214 | en_US |
dc.identifier.scopusauthorid | Tang, OS=7006723402 | en_US |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_US |
dc.identifier.issnl | 0268-1161 | - |