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- Publisher Website: 10.1192/bjp.163.5.627
- Scopus: eid_2-s2.0-0027496755
- PMID: 8298831
- WOS: WOS:A1993MG52100009
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Article: Risk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis?
Title | Risk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis? |
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Authors | |
Issue Date | 1993 |
Publisher | Royal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/ |
Citation | British Journal Of Psychiatry, 1993, v. 163 NOV., p. 627-633 How to Cite? |
Abstract | Recent reports that some influenza epidemics may be followed by a transient increase in the births of schizophrenic patients have led to the hypothesis that maternal viral infections contribute to the aetiology of schizophrenia. It is well known that respiratory viral infections are frequently brought into the home by young children. We tested the predictions that the risk of schizophrenia is decreased in first-born children, and increased in individuals who had siblings of a young age while in utero, using data from a Swedish family study. Our results are consistent with these predictions. In particular, having siblings three to four years older was associated with a significantly increased risk of schizophrenia, even after allowing for birth order, sibship size, and other potential confounders. If replicated, these results provide indirect support for the maternal viral infection hypothesis, although there an alternative explanations. |
Persistent Identifier | http://hdl.handle.net/10722/175687 |
ISSN | 2021 Impact Factor: 10.671 2020 SCImago Journal Rankings: 2.564 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Maclean, CJ | en_US |
dc.contributor.author | Kendler, KS | en_US |
dc.date.accessioned | 2012-11-26T09:00:30Z | - |
dc.date.available | 2012-11-26T09:00:30Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | British Journal Of Psychiatry, 1993, v. 163 NOV., p. 627-633 | en_US |
dc.identifier.issn | 0007-1250 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175687 | - |
dc.description.abstract | Recent reports that some influenza epidemics may be followed by a transient increase in the births of schizophrenic patients have led to the hypothesis that maternal viral infections contribute to the aetiology of schizophrenia. It is well known that respiratory viral infections are frequently brought into the home by young children. We tested the predictions that the risk of schizophrenia is decreased in first-born children, and increased in individuals who had siblings of a young age while in utero, using data from a Swedish family study. Our results are consistent with these predictions. In particular, having siblings three to four years older was associated with a significantly increased risk of schizophrenia, even after allowing for birth order, sibship size, and other potential confounders. If replicated, these results provide indirect support for the maternal viral infection hypothesis, although there an alternative explanations. | en_US |
dc.language | eng | en_US |
dc.publisher | Royal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/ | en_US |
dc.relation.ispartof | British Journal of Psychiatry | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Birth Order | en_US |
dc.subject.mesh | Disease Outbreaks | en_US |
dc.subject.mesh | Family | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Influenza, Human - Complications | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Maternal Welfare | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Prenatal Exposure Delayed Effects | en_US |
dc.subject.mesh | Schizophrenia - Etiology | en_US |
dc.title | Risk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1192/bjp.163.5.627 | - |
dc.identifier.pmid | 8298831 | - |
dc.identifier.scopus | eid_2-s2.0-0027496755 | en_US |
dc.identifier.volume | 163 | en_US |
dc.identifier.issue | NOV. | en_US |
dc.identifier.spage | 627 | en_US |
dc.identifier.epage | 633 | en_US |
dc.identifier.isi | WOS:A1993MG52100009 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | Maclean, CJ=7102972772 | en_US |
dc.identifier.scopusauthorid | Kendler, KS=35396760800 | en_US |
dc.identifier.issnl | 0007-1250 | - |