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Article: DNA pooling: A tool for large-scale association studies

TitleDNA pooling: A tool for large-scale association studies
Authors
Sham, PBader, JSCraig, IO'donovan, MOwen, M
Issue Date2002
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/reviews/genetics
Citation
Nature Reviews Genetics, 2002, v. 3 n. 11, p. 862-871 How to Cite?
DOI: http://dx.doi.org/10.1038/nrg930
AbstractDNA pooling is a practical way to reduce the cost of large-scale association studies to identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups of individuals to be measured using far fewer PCR reactions and genotyping assays than are used when genotyping individuals. Here, we discuss recent developments in quantitative genotyping assays and in the design and analysis of pooling studies. Sophisticated pooling designs are being developed that can take account of hidden population stratification, confounders and inter-loci interactions, and that allow the analysis of haplotypes.
Persistent Identifierhttp://hdl.handle.net/10722/175870
ISSN
1471-0056
2021 Impact Factor: 59.581
2020 SCImago Journal Rankings: 26.214
ISI Accession Number ID
WOS:000179041600014
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorSham, Pen_US
dc.contributor.authorBader, JSen_US
dc.contributor.authorCraig, Ien_US
dc.contributor.authorO'donovan, Men_US
dc.contributor.authorOwen, Men_US
dc.date.accessioned2012-11-26T09:01:56Z-
dc.date.available2012-11-26T09:01:56Z-
dc.date.issued2002en_US
dc.identifier.citationNature Reviews Genetics, 2002, v. 3 n. 11, p. 862-871en_US
dc.identifier.issn1471-0056en_US
dc.identifier.urihttp://hdl.handle.net/10722/175870-
dc.description.abstractDNA pooling is a practical way to reduce the cost of large-scale association studies to identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups of individuals to be measured using far fewer PCR reactions and genotyping assays than are used when genotyping individuals. Here, we discuss recent developments in quantitative genotyping assays and in the design and analysis of pooling studies. Sophisticated pooling designs are being developed that can take account of hidden population stratification, confounders and inter-loci interactions, and that allow the analysis of haplotypes.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/reviews/geneticsen_US
dc.relation.ispartofNature Reviews Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDnaen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Techniquesen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshMutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.titleDNA pooling: A tool for large-scale association studiesen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/nrg930en_US
dc.identifier.pmid12415316-
dc.identifier.scopuseid_2-s2.0-0036844881en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036844881&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume3en_US
dc.identifier.issue11en_US
dc.identifier.spage862en_US
dc.identifier.epage871en_US
dc.identifier.isiWOS:000179041600014-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridBader, JS=7201629332en_US
dc.identifier.scopusauthoridCraig, I=7102548208en_US
dc.identifier.scopusauthoridO'Donovan, M=7103147367en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.citeulike4415004-
dc.identifier.issnl1471-0056-

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