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Article: Furanosesquiterpenoids of Commiphora myrrha

TitleFuranosesquiterpenoids of Commiphora myrrha
Authors
Zhu, NKikuzaki, HSheng, SSang, SRafi, MMWang, MNakatani, NDipaola, RSRosen, RTHo, CT
Issue Date2001
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jnp
Citation
Journal Of Natural Products, 2001, v. 64 n. 11, p. 1460-1462 How to Cite?
DOI: http://dx.doi.org/10.1021/np010072j
AbstractAn investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one(3),rel-2R-methoxy-4R- furanogermacr-1(10)E-en-6-one(4),furanogermacra-1(10)Z,4Z-dien-6-one, 1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5β-isopropenyl-3,6β-dimethyl-6-vinylbenzofuran- 4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay.
Persistent Identifierhttp://hdl.handle.net/10722/178744
ISSN
0163-3864
2021 Impact Factor: 4.803
2020 SCImago Journal Rankings: 0.976
ISI Accession Number ID
WOS:000172496200017
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorZhu, Nen_US
dc.contributor.authorKikuzaki, Hen_US
dc.contributor.authorSheng, Sen_US
dc.contributor.authorSang, Sen_US
dc.contributor.authorRafi, MMen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorNakatani, Nen_US
dc.contributor.authorDipaola, RSen_US
dc.contributor.authorRosen, RTen_US
dc.contributor.authorHo, CTen_US
dc.date.accessioned2012-12-19T09:49:27Z-
dc.date.available2012-12-19T09:49:27Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Natural Products, 2001, v. 64 n. 11, p. 1460-1462en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttp://hdl.handle.net/10722/178744-
dc.description.abstractAn investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one(3),rel-2R-methoxy-4R- furanogermacr-1(10)E-en-6-one(4),furanogermacra-1(10)Z,4Z-dien-6-one, 1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5β-isopropenyl-3,6β-dimethyl-6-vinylbenzofuran- 4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jnpen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.subject.meshAntineoplastic Agents, Phytogenic - Chemistry - Isolation & Purification - Pharmacologyen_US
dc.subject.meshBreast Neoplasmsen_US
dc.subject.meshBurseraceae - Chemistryen_US
dc.subject.meshChromatography, Thin Layeren_US
dc.subject.meshDrugs, Chinese Herbal - Chemistry - Isolation & Purification - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Conformationen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshNuclear Magnetic Resonance, Biomolecularen_US
dc.subject.meshPlants, Medicinal - Chemistryen_US
dc.subject.meshSesquiterpenes - Chemistry - Isolation & Purification - Pharmacologyen_US
dc.subject.meshSesquiterpenes, Germacraneen_US
dc.subject.meshStereoisomerismen_US
dc.subject.meshTumor Cells, Cultured - Drug Effectsen_US
dc.titleFuranosesquiterpenoids of Commiphora myrrhaen_US
dc.typeArticleen_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/np010072jen_US
dc.identifier.pmid11720534-
dc.identifier.scopuseid_2-s2.0-0035195802en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035195802&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume64en_US
dc.identifier.issue11en_US
dc.identifier.spage1460en_US
dc.identifier.epage1462en_US
dc.identifier.isiWOS:000172496200017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhu, N=7201449552en_US
dc.identifier.scopusauthoridKikuzaki, H=7003452974en_US
dc.identifier.scopusauthoridSheng, S=7102347594en_US
dc.identifier.scopusauthoridSang, S=7006277967en_US
dc.identifier.scopusauthoridRafi, MM=7005112935en_US
dc.identifier.scopusauthoridWang, M=7406691844en_US
dc.identifier.scopusauthoridNakatani, N=7102434865en_US
dc.identifier.scopusauthoridDiPaola, RS=7004220521en_US
dc.identifier.scopusauthoridRosen, RT=7202895150en_US
dc.identifier.scopusauthoridHo, CT=7404652573en_US
dc.identifier.issnl0163-3864-

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