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Conference Paper: Views on issues in radiation biodosimetry based on chromosome translocations measured by FISH

TitleViews on issues in radiation biodosimetry based on chromosome translocations measured by FISH
Other TitlesOur views on issues in radiation biodosimetry based on chromosome translocations measured by FISH
Authors
Lucas, JNDeng, W
Issue Date2000
PublisherOxford University Press. The Journal's web site is located at http://rpd.oxfordjournals.org/
Citation
Radiation Protection Dosimetry, 2000, v. 88 n. 1, p. 77-86 How to Cite?
DOI: http://dx.doi.org/10.1093/oxfordjournals.rpd.a033024
AbstractA biomarker for retrospective biodosimetry for radiation exposure and human health risk assessment would be most useful if it employed an endpoint that is highly quantitative, is stable over time, and is relevant to human health risk. The frequency of chromosome translocations in individuals exposed to low to medium doses of whole-body radiation serves these goals. Recent advances in chromosome painting using fluorescence in situ hybridisation (FISH) facilitate fast and reliable measurement of chromosome translocations, a kind of DNA damage linked to both prior clastogenic exposure and to human health risk. Here, results from this laboratory on issues of FISH-based radiation biodosimetry are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/179618
ISSN
0144-8420
2021 Impact Factor: 0.954
2020 SCImago Journal Rankings: 0.392
ISI Accession Number ID
WOS:000087035500011
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLucas, JNen_US
dc.contributor.authorDeng, Wen_US
dc.date.accessioned2012-12-19T10:01:09Z-
dc.date.available2012-12-19T10:01:09Z-
dc.date.issued2000en_US
dc.identifier.citationRadiation Protection Dosimetry, 2000, v. 88 n. 1, p. 77-86en_US
dc.identifier.issn0144-8420en_US
dc.identifier.urihttp://hdl.handle.net/10722/179618-
dc.description.abstractA biomarker for retrospective biodosimetry for radiation exposure and human health risk assessment would be most useful if it employed an endpoint that is highly quantitative, is stable over time, and is relevant to human health risk. The frequency of chromosome translocations in individuals exposed to low to medium doses of whole-body radiation serves these goals. Recent advances in chromosome painting using fluorescence in situ hybridisation (FISH) facilitate fast and reliable measurement of chromosome translocations, a kind of DNA damage linked to both prior clastogenic exposure and to human health risk. Here, results from this laboratory on issues of FISH-based radiation biodosimetry are discussed.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://rpd.oxfordjournals.org/en_US
dc.relation.ispartofRadiation Protection Dosimetryen_US
dc.titleViews on issues in radiation biodosimetry based on chromosome translocations measured by FISHen_US
dc.title.alternativeOur views on issues in radiation biodosimetry based on chromosome translocations measured by FISH-
dc.typeConference_Paperen_US
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_US
dc.identifier.authorityDeng, W=rp01640en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/oxfordjournals.rpd.a033024-
dc.identifier.scopuseid_2-s2.0-0034026871en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034026871&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume88en_US
dc.identifier.issue1en_US
dc.identifier.spage77en_US
dc.identifier.epage86en_US
dc.identifier.isiWOS:000087035500011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLucas, JN=7402441937en_US
dc.identifier.scopusauthoridDeng, W=7202223673en_US
dc.customcontrol.immutablesml 160531 amended-
dc.identifier.issnl0144-8420-

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