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Article: Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation

TitleSpinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation
Authors
Zhang, RXLiu, BLao, LQiao, JTRuda, MA
KeywordsComplete Freund's adjuvant
Hyperalgesia
Neonates
Preprodynorphin mRNA
Rats
Spinal dorsal horn
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2005, v. 1038 n. 2, p. 238-242 How to Cite?
DOI: http://dx.doi.org/10.1016/j.brainres.2005.01.039
AbstractSpinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188560
ISSN
0006-8993
2021 Impact Factor: 3.610
2020 SCImago Journal Rankings: 1.037
ISI Accession Number ID
WOS:000228195700013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorLao, Len_US
dc.contributor.authorQiao, JTen_US
dc.contributor.authorRuda, MAen_US
dc.date.accessioned2013-09-03T04:10:16Z-
dc.date.available2013-09-03T04:10:16Z-
dc.date.issued2005en_US
dc.identifier.citationBrain Research, 2005, v. 1038 n. 2, p. 238-242en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/188560-
dc.description.abstractSpinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations. © 2005 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subjectComplete Freund's adjuvant-
dc.subjectHyperalgesia-
dc.subjectNeonates-
dc.subjectPreprodynorphin mRNA-
dc.subjectRats-
dc.subjectSpinal dorsal horn-
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newborn - Metabolismen_US
dc.subject.meshBehavior, Animal - Drug Effectsen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshDynorphins - Biosynthesisen_US
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_US
dc.subject.meshInflammation - Metabolismen_US
dc.subject.meshProtein Precursors - Biosynthesisen_US
dc.subject.meshRna, Messenger - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshSpinal Cord - Metabolismen_US
dc.subject.meshUp-Regulation - Geneticsen_US
dc.titleSpinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2005.01.039en_US
dc.identifier.pmid15757640en_US
dc.identifier.scopuseid_2-s2.0-14744283685en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14744283685&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1038en_US
dc.identifier.issue2en_US
dc.identifier.spage238en_US
dc.identifier.epage242en_US
dc.identifier.isiWOS:000228195700013-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridLiu, B=55720712900en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridQiao, JT=7103301572en_US
dc.identifier.scopusauthoridRuda, MA=7005152163en_US
dc.identifier.issnl0006-8993-

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