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- Publisher Website: 10.1007/978-1-61779-561-9_20
- Scopus: eid_2-s2.0-84858120644
- PMID: 22351098
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Article: A new rat model of bone cancer pain
Title | A new rat model of bone cancer pain |
---|---|
Authors | |
Keywords | Allodynia Bone cancer pain Hyperalgesia Immuno-histochemistry Immunofluorescence Metastatic bone tumors Rat |
Issue Date | 2012 |
Citation | Methods In Molecular Biology, 2012, v. 851, p. 261-273 How to Cite? |
Abstract | Pain is a major symptom of bone cancer. Bone cancer pain significantly affects quality of life, but its underlying mechanisms have not been defined. Because skeletal metastases are particularly common in patients with prostate cancer, a model that mimics bone cancer pain has been established by injecting AT-3.1 prostate cancer cells into the tibia of the male Copenhagen rat. The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders. © 2012 Springer Science+Business Media, LLC. |
Persistent Identifier | http://hdl.handle.net/10722/188645 |
ISSN | 2020 SCImago Journal Rankings: 0.711 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, R | en_US |
dc.contributor.author | Lao, L | en_US |
dc.date.accessioned | 2013-09-03T04:10:47Z | - |
dc.date.available | 2013-09-03T04:10:47Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Methods In Molecular Biology, 2012, v. 851, p. 261-273 | en_US |
dc.identifier.issn | 1064-3745 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188645 | - |
dc.description.abstract | Pain is a major symptom of bone cancer. Bone cancer pain significantly affects quality of life, but its underlying mechanisms have not been defined. Because skeletal metastases are particularly common in patients with prostate cancer, a model that mimics bone cancer pain has been established by injecting AT-3.1 prostate cancer cells into the tibia of the male Copenhagen rat. The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders. © 2012 Springer Science+Business Media, LLC. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Methods in Molecular Biology | en_US |
dc.subject | Allodynia | - |
dc.subject | Bone cancer pain | - |
dc.subject | Hyperalgesia | - |
dc.subject | Immuno-histochemistry | - |
dc.subject | Immunofluorescence | - |
dc.subject | Metastatic bone tumors | - |
dc.subject | Rat | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bone Neoplasms - Complications - Pathology - Physiopathology | en_US |
dc.subject.mesh | Cell Line, Tumor | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Hyperalgesia - Pathology - Physiopathology | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pain - Etiology - Pathology - Physiopathology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Tibia - Pathology - Physiopathology | en_US |
dc.title | A new rat model of bone cancer pain | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/978-1-61779-561-9_20 | en_US |
dc.identifier.pmid | 22351098 | - |
dc.identifier.scopus | eid_2-s2.0-84858120644 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84858120644&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 851 | en_US |
dc.identifier.spage | 261 | en_US |
dc.identifier.epage | 273 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhang, R=7404864527 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.issnl | 1064-3745 | - |