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Article: Perfusion and diffusion characteristics of cervical cancer based on intraxovel incoherent motion MR imaging: a pilot study

TitlePerfusion and diffusion characteristics of cervical cancer based on intraxovel incoherent motion MR imaging: a pilot study
Authors
Issue Date2014
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm
Citation
European Radiology, 2014, v. 24 n. 7, p. 1506-1513 How to Cite?
AbstractObjectives To investigate the tissue characteristics of cervical cancer based on intravoxel incoherent motion (IVIM) model and to differentiate cervical cancer from non-malignant tissues based on the IVIM characteristics. Methods Sixteen treatment-naïve cervical cancer and 17 age-matched healthy subjects were prospectively recruited for diffusion-weighted (b=0-1000 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive the perfusion parameters, f (perfusion fraction), D* (pseudodiffusion coefficient) and the diffusion parameter, D (true molecular diffusion coefficient) in cervical cancer, normal cervix, myometrium and leiomyoma. Apparent diffusion coefficient (ADC) was calculated. Kruskal-Wallis test and receiver operating characteristics (ROC) curves were used. Results Cervical cancer had the lowest f (14.9±2.6%), significantly different from normal cervix and leiomyoma (p<0.05). The D (0.86±0.16 x 103 mm2/s) was also lowest in cervical cancer, significantly different from normal cervix and myometrium (p<0.05) but not with leiomyoma. No difference was observed in D*. D was consistently lower than ADC in all tissues. ROC curves identified f < 16.38%, D < 1.04 x 103 mm2/s and ADC <1.13 x 103 mm2/s could differentiate cervical cancer from non-malignant tissues (AUC: 0.773-0.908). Conclusions Cervical cancer has low perfusion and diffusion IVIM characteristics that allow differentiation from non-malignant tissues.
Persistent Identifierhttp://hdl.handle.net/10722/196562
ISSN
2017 Impact Factor: 4.027
2015 SCImago Journal Rankings: 2.064

 

DC FieldValueLanguage
dc.contributor.authorLee, EYPen_US
dc.contributor.authorYU, Xen_US
dc.contributor.authorChu, MMYen_US
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorSiu, SWKen_US
dc.contributor.authorSoong, ISen_US
dc.contributor.authorChan, Qen_US
dc.contributor.authorKhong, PLen_US
dc.date.accessioned2014-04-22T08:35:52Z-
dc.date.available2014-04-22T08:35:52Z-
dc.date.issued2014en_US
dc.identifier.citationEuropean Radiology, 2014, v. 24 n. 7, p. 1506-1513en_US
dc.identifier.issn0938-7994en_US
dc.identifier.urihttp://hdl.handle.net/10722/196562-
dc.description.abstractObjectives To investigate the tissue characteristics of cervical cancer based on intravoxel incoherent motion (IVIM) model and to differentiate cervical cancer from non-malignant tissues based on the IVIM characteristics. Methods Sixteen treatment-naïve cervical cancer and 17 age-matched healthy subjects were prospectively recruited for diffusion-weighted (b=0-1000 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive the perfusion parameters, f (perfusion fraction), D* (pseudodiffusion coefficient) and the diffusion parameter, D (true molecular diffusion coefficient) in cervical cancer, normal cervix, myometrium and leiomyoma. Apparent diffusion coefficient (ADC) was calculated. Kruskal-Wallis test and receiver operating characteristics (ROC) curves were used. Results Cervical cancer had the lowest f (14.9±2.6%), significantly different from normal cervix and leiomyoma (p<0.05). The D (0.86±0.16 x 103 mm2/s) was also lowest in cervical cancer, significantly different from normal cervix and myometrium (p<0.05) but not with leiomyoma. No difference was observed in D*. D was consistently lower than ADC in all tissues. ROC curves identified f < 16.38%, D < 1.04 x 103 mm2/s and ADC <1.13 x 103 mm2/s could differentiate cervical cancer from non-malignant tissues (AUC: 0.773-0.908). Conclusions Cervical cancer has low perfusion and diffusion IVIM characteristics that allow differentiation from non-malignant tissues.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htmen_US
dc.relation.ispartofEuropean Radiologyen_US
dc.rightsThe original publication is available at www.springerlink.comen_US
dc.titlePerfusion and diffusion characteristics of cervical cancer based on intraxovel incoherent motion MR imaging: a pilot studyen_US
dc.typeArticleen_US
dc.identifier.emailLee, EYP: eyplee77@hku.hken_US
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_US
dc.identifier.emailKhong, PL: plkhong@hku.hken_US
dc.identifier.authorityLee, EYP=rp01456en_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.identifier.authorityKhong, PL=rp00467en_US
dc.identifier.doi10.1007/s00330-014-3160-7-
dc.identifier.hkuros228544en_US
dc.publisher.placeGermanyen_US

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