MODIFIED BACTERIA AND USES THEREOF FOR TREATMENT OF CANCER OR TUMOR

Abstract

Provided are a method for treating cancer or tumor by using modified bacteria as well as a therapeutic or prophylactic composition comprising the modified bacteria. The method may combine with other treatments such as chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. Further provided are the modified bacteria comprising an essential gene expressing cassette that is strictly hypoxia regulated as well as the vector comprising the same. The modified bacteria grow within the solid tumor/cancer, rendering the retardation or elimination of the tumor/cancer from normal tissues. Also provided is the use of the modified bacteria in manufacturing a medicament for treating cancer.