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Conference Paper: Further evidence that the 3’Untranslated Region of the CHOP mRNA possesses mRNA destabilizing effect
| Title | Further evidence that the 3’Untranslated Region of the CHOP mRNA possesses mRNA destabilizing effect |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 23, poster no. 22 How to Cite? |
| Abstract | The transcription regulatory factor known as Chop is commonly induced to express in stressed cells. In most cases, the expression of CHOP is associated with apoptosis. Although the regulation of CHOP expression at the transcriptional level has been studied to considerable details, the involvement of post-transcriptional mechanism such as mRNA stability has not been much addressed. We previously provided indirect evidence that the 3’UTR of CHOP mRNA had an mRNA destabilizing effect. The objective of this study was to provide more direct evidence to support this hypothesis. A reporter plasmid was constructed so as to express an EGFP mRNA that has its original ... |
| Description | Poster presentation - Theme 1: Cell biology |
| Persistent Identifier | http://hdl.handle.net/10722/203852 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wong, PY | en_US |
| dc.contributor.author | Wong, NS | en_US |
| dc.date.accessioned | 2014-09-19T16:42:19Z | - |
| dc.date.available | 2014-09-19T16:42:19Z | - |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 23, poster no. 22 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/203852 | - |
| dc.description | Poster presentation - Theme 1: Cell biology | - |
| dc.description.abstract | The transcription regulatory factor known as Chop is commonly induced to express in stressed cells. In most cases, the expression of CHOP is associated with apoptosis. Although the regulation of CHOP expression at the transcriptional level has been studied to considerable details, the involvement of post-transcriptional mechanism such as mRNA stability has not been much addressed. We previously provided indirect evidence that the 3’UTR of CHOP mRNA had an mRNA destabilizing effect. The objective of this study was to provide more direct evidence to support this hypothesis. A reporter plasmid was constructed so as to express an EGFP mRNA that has its original ... | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | Hong Kong Inter-University Biochemistry Postgraduate Symposium | en_US |
| dc.title | Further evidence that the 3’Untranslated Region of the CHOP mRNA possesses mRNA destabilizing effect | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Wong, NS: nswong@hku.hk | en_US |
| dc.identifier.authority | Wong, NS=rp00340 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 240330 | en_US |
| dc.identifier.hkuros | 270511 | - |
| dc.identifier.spage | 23, poster no. 22 | - |
| dc.identifier.epage | 23, poster no. 22 | - |