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Article: Acute myeloid leukaemia with giant granules: association with t(10;11)(p13;q14) and disseminated intravascular coagulation

TitleAcute myeloid leukaemia with giant granules: association with t(10;11)(p13;q14) and disseminated intravascular coagulation
Authors
Ma, SKYip, SFWan, TSKShek, TWHChing, LMYeung, YM
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLH
Citation
Clinical and Laboratory Haematology, 2001, v. 22 n. 5, p. 303-305 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2257.2000.00329.x
AbstractA 16-year-old Chinese girl presented with AML-M5a. A bone marrow examination showed that the myeloblasts which were overwhelming the marrow contained giant granules (pseudo-Chediak-Higashi anomaly). Her karyotype showed a rare translocation t(10; 11)(p13; q14). Molecular delineation of the translocation breakpoints was not possible. Nonetheless, this case further demonstrates the morphological and phenotypic heterogeneity of acute leukaemia with this translocation. In this girl it was associated with disseminated intravascular coagulation.
Persistent Identifierhttp://hdl.handle.net/10722/211389
ISSN
0141-9854
ISI Accession Number ID
WOS:000165827500011

 

DC FieldValueLanguage
dc.contributor.authorMa, SK-
dc.contributor.authorYip, SF-
dc.contributor.authorWan, TSK-
dc.contributor.authorShek, TWH-
dc.contributor.authorChing, LM-
dc.contributor.authorYeung, YM-
dc.date.accessioned2015-07-10T02:36:08Z-
dc.date.available2015-07-10T02:36:08Z-
dc.date.issued2001-
dc.identifier.citationClinical and Laboratory Haematology, 2001, v. 22 n. 5, p. 303-305-
dc.identifier.issn0141-9854-
dc.identifier.urihttp://hdl.handle.net/10722/211389-
dc.description.abstractA 16-year-old Chinese girl presented with AML-M5a. A bone marrow examination showed that the myeloblasts which were overwhelming the marrow contained giant granules (pseudo-Chediak-Higashi anomaly). Her karyotype showed a rare translocation t(10; 11)(p13; q14). Molecular delineation of the translocation breakpoints was not possible. Nonetheless, this case further demonstrates the morphological and phenotypic heterogeneity of acute leukaemia with this translocation. In this girl it was associated with disseminated intravascular coagulation.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLH-
dc.relation.ispartofClinical and Laboratory Haematology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshBone Marrow Cells - metabolism - pathology - ultrastructure-
dc.subject.meshCytoplasmic Granules - pathology - ultrastructure-
dc.subject.meshDisseminated Intravascular Coagulation - pathology-
dc.subject.meshLeukemia, Monocytic, Acute - genetics - pathology-
dc.subject.meshMicroscopy, Electron-
dc.titleAcute myeloid leukaemia with giant granules: association with t(10;11)(p13;q14) and disseminated intravascular coagulation-
dc.typeArticle-
dc.identifier.emailMa, SK: eskma@hkucc.hku.hk-
dc.identifier.emailWan, TSK: wantsk@hkucc.hku.hk-
dc.identifier.doi10.1046/j.1365-2257.2000.00329.x-
dc.identifier.pmid11122274-
dc.identifier.scopuseid_2-s2.0-0034518741-
dc.identifier.hkuros63690-
dc.identifier.volume22-
dc.identifier.issue5-
dc.identifier.spage303-
dc.identifier.epage305-
dc.identifier.isiWOS:000165827500011-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0141-9854-

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