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Article: Imaging and measuring the rituximab-induced changes of mechanical properties in B-lymphoma cells using atomic force microscopy

TitleImaging and measuring the rituximab-induced changes of mechanical properties in B-lymphoma cells using atomic force microscopy
Authors
Li, MiLiu, LianqingXi, NingWang, YuechaoDong, ZailiTabata, OsamuXiao, XiubinZhang, Weijing
KeywordsAtomic force microscopy
Young's modulus
Rituximab
Mechanical properties
Issue Date2011
Citation
Biochemical and Biophysical Research Communications, 2011, v. 404, n. 2, p. 689-694 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bbrc.2010.12.043
AbstractThe topography and mechanical properties of single B-lymphoma cells have been investigated by atomic force microscopy (AFM). With the assistance of microfabricated patterned pillars, the surface topography and ultrastructure of single living B-lymphoma cell were visualized by AFM. The apoptosis of B-lymphoma cells induced by rituximab alone was observed by acridine orange/ethidium bromide (AO/EB) double fluorescent staining. The rituximab-induced changes of mechanical properties in B-lymphoma cells were measured dynamically and the results showed that B-lymphoma cells became dramatically softer after incubation with rituximab. These results can improve our understanding of rituximab'effect and will facilitate the further investigation of the underlying mechanisms. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/213134
ISSN
0006-291X
2021 Impact Factor: 3.322
2020 SCImago Journal Rankings: 0.998
ISI Accession Number ID
WOS:000286543800020

 

DC FieldValueLanguage
dc.contributor.authorLi, Mi-
dc.contributor.authorLiu, Lianqing-
dc.contributor.authorXi, Ning-
dc.contributor.authorWang, Yuechao-
dc.contributor.authorDong, Zaili-
dc.contributor.authorTabata, Osamu-
dc.contributor.authorXiao, Xiubin-
dc.contributor.authorZhang, Weijing-
dc.date.accessioned2015-07-28T04:06:14Z-
dc.date.available2015-07-28T04:06:14Z-
dc.date.issued2011-
dc.identifier.citationBiochemical and Biophysical Research Communications, 2011, v. 404, n. 2, p. 689-694-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10722/213134-
dc.description.abstractThe topography and mechanical properties of single B-lymphoma cells have been investigated by atomic force microscopy (AFM). With the assistance of microfabricated patterned pillars, the surface topography and ultrastructure of single living B-lymphoma cell were visualized by AFM. The apoptosis of B-lymphoma cells induced by rituximab alone was observed by acridine orange/ethidium bromide (AO/EB) double fluorescent staining. The rituximab-induced changes of mechanical properties in B-lymphoma cells were measured dynamically and the results showed that B-lymphoma cells became dramatically softer after incubation with rituximab. These results can improve our understanding of rituximab'effect and will facilitate the further investigation of the underlying mechanisms. © 2010 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofBiochemical and Biophysical Research Communications-
dc.subjectAtomic force microscopy-
dc.subjectYoung's modulus-
dc.subjectRituximab-
dc.subjectMechanical properties-
dc.titleImaging and measuring the rituximab-induced changes of mechanical properties in B-lymphoma cells using atomic force microscopy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2010.12.043-
dc.identifier.pmid21156157-
dc.identifier.scopuseid_2-s2.0-78651367788-
dc.identifier.volume404-
dc.identifier.issue2-
dc.identifier.spage689-
dc.identifier.epage694-
dc.identifier.eissn1090-2104-
dc.identifier.isiWOS:000286543800020-
dc.identifier.issnl0006-291X-

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