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Article: A Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex

TitleA Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex
Authors
He, LChen, TYou, YHu, HZheng, WKwong, WLZou, TChe, CM
KeywordsDrug delivery
Gold
Mesoporous materials
Porphyrins
Silica nanoparticles
Issue Date2014
PublisherWiley.
Citation
Angewandte Chemie International Edition, 2014, v. 53, p. 12532-12536 How to Cite?
DOI: http://dx.doi.org/10.1002/anie.201407143
AbstractConstruction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.
Persistent Identifierhttp://hdl.handle.net/10722/215135
ISI Accession Number ID
WOS:000344649900031

 

DC FieldValueLanguage
dc.contributor.authorHe, L-
dc.contributor.authorChen, T-
dc.contributor.authorYou, Y-
dc.contributor.authorHu, H-
dc.contributor.authorZheng, W-
dc.contributor.authorKwong, WL-
dc.contributor.authorZou, T-
dc.contributor.authorChe, CM-
dc.date.accessioned2015-08-21T13:15:25Z-
dc.date.available2015-08-21T13:15:25Z-
dc.date.issued2014-
dc.identifier.citationAngewandte Chemie International Edition, 2014, v. 53, p. 12532-12536-
dc.identifier.urihttp://hdl.handle.net/10722/215135-
dc.description.abstractConstruction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.-
dc.languageeng-
dc.publisherWiley.-
dc.relation.ispartofAngewandte Chemie International Edition-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. In addition, authors may also transmit, print and share copies with colleagues, provided that there is no systematic distribution of the submitted version, e.g. posting on a listserve, network or automated delivery.-
dc.subjectDrug delivery-
dc.subjectGold-
dc.subjectMesoporous materials-
dc.subjectPorphyrins-
dc.subjectSilica nanoparticles-
dc.titleA Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex-
dc.typeArticle-
dc.identifier.emailKwong, WL: kwongwl@hku.hk-
dc.identifier.emailZou, T: zoutt@hku.hk-
dc.identifier.emailChe, CM: cmche@hku.hk-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.doi10.1002/anie.201407143-
dc.identifier.scopuseid_2-s2.0-84915767305-
dc.identifier.hkuros246899-
dc.identifier.volume53-
dc.identifier.spage12532-
dc.identifier.epage12536-
dc.identifier.isiWOS:000344649900031-
dc.publisher.placeWeinheim, Germany-

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