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Conference Paper: Chronic intermittent hypoxia induces depressive-like behavior in rats

TitleChronic intermittent hypoxia induces depressive-like behavior in rats
Authors
Lam, CSLiu, YYTipoe, GLFung, ML
Issue Date2014
PublisherMedcom Limited. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2014), Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 55, abstract CP8 How to Cite?
AbstractObstructive sleep apnea (OSA) causes recurrent oxygen desaturation (chronic intermittent hypoxia, CIH) and is associated with depression in patients. However, the relationship between OSA and depression is unclear. Synaptic degeneration, microtubule instability and monoamine deficiency are the common pathological features exhibited in both patients and depression animal models. We hypothesized that CIH induces depressive-like behavior by triggering synaptic degeneration, microtubule instability, and reducing monoamine downstream signaling deficits in the hippocampus. Adult male SD rats were exposed to air (normoxic) control or CIH treatment (8 hours/day) for 7 days. Hippocampus was harvested for the measurement of markers for synaptic vesicle protein ...
Persistent Identifierhttp://hdl.handle.net/10722/218939
ISSN
1027-7811
2020 SCImago Journal Rankings: 0.105

 

DC FieldValueLanguage
dc.contributor.authorLam, CS-
dc.contributor.authorLiu, YY-
dc.contributor.authorTipoe, GL-
dc.contributor.authorFung, ML-
dc.date.accessioned2015-09-18T07:01:35Z-
dc.date.available2015-09-18T07:01:35Z-
dc.date.issued2014-
dc.identifier.citationThe 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2014), Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 55, abstract CP8-
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/218939-
dc.description.abstractObstructive sleep apnea (OSA) causes recurrent oxygen desaturation (chronic intermittent hypoxia, CIH) and is associated with depression in patients. However, the relationship between OSA and depression is unclear. Synaptic degeneration, microtubule instability and monoamine deficiency are the common pathological features exhibited in both patients and depression animal models. We hypothesized that CIH induces depressive-like behavior by triggering synaptic degeneration, microtubule instability, and reducing monoamine downstream signaling deficits in the hippocampus. Adult male SD rats were exposed to air (normoxic) control or CIH treatment (8 hours/day) for 7 days. Hippocampus was harvested for the measurement of markers for synaptic vesicle protein ...-
dc.languageeng-
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiology-
dc.titleChronic intermittent hypoxia induces depressive-like behavior in rats-
dc.typeConference_Paper-
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hk-
dc.identifier.emailFung, ML: fungml@hku.hk-
dc.identifier.authorityTipoe, GL=rp00371-
dc.identifier.authorityFung, ML=rp00433-
dc.description.naturepostprint-
dc.identifier.hkuros252335-
dc.identifier.volume22-
dc.identifier.issue2-
dc.identifier.spage55, abstract CP8-
dc.identifier.epage55, abstract CP8-
dc.publisher.placeHong Kong-
dc.identifier.issnl1027-7811-

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