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Conference Paper: Evaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging
| Title | Evaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging |
|---|---|
| Authors | |
| Issue Date | 2015 |
| Citation | The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) & SMRT 24th Annual Meeting, Toronto, ON., Canada, 30-31 May 2015. How to Cite? |
| Abstract | In this study, we evaluated the age-related change in glutamatergic metabolism and its role in neurovascular coupling via quantitiave proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in anterior cingulate cortex (ACC). Glutamine concentration was found to increase with age, whereas as both global and regional cerebral blood flow (CBF) in ACC showed age-related decline. However, no direct relationship was found between CBF and glutamatergic synaptic activity in aging suggesting the age-related alteration in glutamatergic metabolism might not directly affect CBF. |
| Description | Traditional Poster Session • MR Spectroscopy, Spectroscopic & Non-Proton Imaging, ESR - MRS Normal & Ageing Brain: no. 2006 |
| Persistent Identifier | http://hdl.handle.net/10722/220244 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chiu, PW | - |
| dc.contributor.author | Liu, P | - |
| dc.contributor.author | Chan, Q | - |
| dc.contributor.author | Chang, RCC | - |
| dc.contributor.author | Chu, LW | - |
| dc.contributor.author | Lu, H | - |
| dc.contributor.author | Mak, HKF | - |
| dc.date.accessioned | 2015-10-16T06:33:31Z | - |
| dc.date.available | 2015-10-16T06:33:31Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) & SMRT 24th Annual Meeting, Toronto, ON., Canada, 30-31 May 2015. | - |
| dc.identifier.uri | http://hdl.handle.net/10722/220244 | - |
| dc.description | Traditional Poster Session • MR Spectroscopy, Spectroscopic & Non-Proton Imaging, ESR - MRS Normal & Ageing Brain: no. 2006 | - |
| dc.description.abstract | In this study, we evaluated the age-related change in glutamatergic metabolism and its role in neurovascular coupling via quantitiave proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in anterior cingulate cortex (ACC). Glutamine concentration was found to increase with age, whereas as both global and regional cerebral blood flow (CBF) in ACC showed age-related decline. However, no direct relationship was found between CBF and glutamatergic synaptic activity in aging suggesting the age-related alteration in glutamatergic metabolism might not directly affect CBF. | - |
| dc.language | eng | - |
| dc.relation.ispartof | ISMRM / SMRT 2015 | - |
| dc.title | Evaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Chang, RCC: rccchang@hku.hk | - |
| dc.identifier.email | Chu, LW: lwchu@hkucc.hku.hk | - |
| dc.identifier.email | Mak, HKF: makkf@hkucc.hku.hk | - |
| dc.identifier.authority | Chang, RCC=rp00470 | - |
| dc.identifier.authority | Mak, HKF=rp00533 | - |
| dc.identifier.hkuros | 255761 | - |