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- Publisher Website: 10.1073/pnas.1504174112
- Scopus: eid_2-s2.0-84935826142
- WOS: WOS:000356251800065
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Article: A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions
Title | A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions |
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Authors | |
Keywords | Pseudotyping Rab coupling protein FIP1C HIV assembly HIV envelope |
Issue Date | 2015 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2015, v. 112, n. 24, p. 7575-7580 How to Cite? |
Abstract | © 2015, National Academy of Sciences. All rights reserved. Lentiviruses such as HIV-1 encode envelope glycoproteins (Env) with long cytoplasmic tails (CTs) that include motifs mediating interactions with host-cell-trafficking factors. We demonstrated recently that Rab11-family interacting protein 1C (FIP1C) is required for CT-dependent incorporation of Env into HIV-1 particles. Here, we used viruses bearing targeted substitutions within CT to map the FIP1C-dependent incorporation of Env. We identified YW |
Persistent Identifier | http://hdl.handle.net/10722/222689 |
ISSN | 2021 Impact Factor: 12.779 2020 SCImago Journal Rankings: 5.011 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Qi, Mingli | - |
dc.contributor.author | Chu, Hin | - |
dc.contributor.author | Chen, Xuemin | - |
dc.contributor.author | Choi, Junghwa | - |
dc.contributor.author | Wen, Xiaoyun | - |
dc.contributor.author | Hammonds, Jason | - |
dc.contributor.author | Ding, Lingmei | - |
dc.contributor.author | Hunter, Eric | - |
dc.contributor.author | Spearman, Paul | - |
dc.date.accessioned | 2016-01-19T03:37:00Z | - |
dc.date.available | 2016-01-19T03:37:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2015, v. 112, n. 24, p. 7575-7580 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/222689 | - |
dc.description.abstract | © 2015, National Academy of Sciences. All rights reserved. Lentiviruses such as HIV-1 encode envelope glycoproteins (Env) with long cytoplasmic tails (CTs) that include motifs mediating interactions with host-cell-trafficking factors. We demonstrated recently that Rab11-family interacting protein 1C (FIP1C) is required for CT-dependent incorporation of Env into HIV-1 particles. Here, we used viruses bearing targeted substitutions within CT to map the FIP1C-dependent incorporation of Env. We identified YW<inf>795</inf> as a critical motif mediating cell-type-dependent Env incorporation. Disruption of YW<inf>795</inf> reproduced the cell-type-dependent particle incorporation of Env that had previously been observed with large truncations of CT. A revertant virus bearing a single amino acid change near the C terminus of CT restored wild-type levels of Env incorporation, Gag-Env colocalization on the plasma membrane, and viral replication. These findings highlight the importance of YW<inf>795</inf> in the cell-type-dependent incorporation of Env and support a model of HIV assembly in which FIP1C/RCP mediates Env trafficking to the particle assembly site. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject | Pseudotyping | - |
dc.subject | Rab coupling protein | - |
dc.subject | FIP1C | - |
dc.subject | HIV assembly | - |
dc.subject | HIV envelope | - |
dc.title | A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.1504174112 | - |
dc.identifier.scopus | eid_2-s2.0-84935826142 | - |
dc.identifier.volume | 112 | - |
dc.identifier.issue | 24 | - |
dc.identifier.spage | 7575 | - |
dc.identifier.epage | 7580 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.isi | WOS:000356251800065 | - |
dc.identifier.issnl | 0027-8424 | - |