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- Publisher Website: 10.1517/14740338.2016.1139573
- Scopus: eid_2-s2.0-84959509417
- PMID: 26752687
- WOS: WOS:000371330700002
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Article: DNA polymerase inhibitors for treating hepatitis B: a safety evaluation
Title | DNA polymerase inhibitors for treating hepatitis B: a safety evaluation |
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Authors | |
Keywords | Breast feeding Chronic hepatitis B DNA polymerase inhibitor Fanconi syndrome Lactic acidosis Muscle toxicity Myopathy Nephrotoxicity Nucleoside/ nucleotide analogue Osteomalacia Peripheral neuropathy Teratogenecity |
Issue Date | 2016 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eds |
Citation | Expert Opinion on Drug Safety, 2016, v. 15 n. 3, p. 383-392 How to Cite? |
Abstract | Introduction: Oral nucleoside/ nucleotide analogues (NAs) are currently the mainstay of treatment for patients with chronic hepatitis B virus (HBV) infection. They are generally safe to use. However, since their approval in the last decade and a half, the literature has reported adverse effects associated with the use of NA in HBV patients. A comprehensive review on the drug safety is lacking.
Areas covered: Significant adverse effects associated with NA use in HBV patients including muscle toxicity, peripheral neuropathy, nephrotoxicity and lactic acidosis are discussed. The reported prevalence of each adverse effect, as well as their predictive factors, reversibility and their use in pregnancy and lactating mothers are covered in this review. Novel data regarding reno-protective effect of telbivudine are also discussed.
Expert opinion: Use of NA in HBV is generally safe. Uncommon adverse effects can be minimized or detected early if clinicians exercise adequate precautions when using NA for at-risk populations with regular monitoring. |
Persistent Identifier | http://hdl.handle.net/10722/226355 |
ISSN | 2021 Impact Factor: 4.011 2020 SCImago Journal Rankings: 1.086 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mak, LY | - |
dc.contributor.author | Seto, WK | - |
dc.contributor.author | Lai, CL | - |
dc.contributor.author | Yuen, MF | - |
dc.date.accessioned | 2016-06-17T07:43:35Z | - |
dc.date.available | 2016-06-17T07:43:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Expert Opinion on Drug Safety, 2016, v. 15 n. 3, p. 383-392 | - |
dc.identifier.issn | 1474-0338 | - |
dc.identifier.uri | http://hdl.handle.net/10722/226355 | - |
dc.description.abstract | Introduction: Oral nucleoside/ nucleotide analogues (NAs) are currently the mainstay of treatment for patients with chronic hepatitis B virus (HBV) infection. They are generally safe to use. However, since their approval in the last decade and a half, the literature has reported adverse effects associated with the use of NA in HBV patients. A comprehensive review on the drug safety is lacking. Areas covered: Significant adverse effects associated with NA use in HBV patients including muscle toxicity, peripheral neuropathy, nephrotoxicity and lactic acidosis are discussed. The reported prevalence of each adverse effect, as well as their predictive factors, reversibility and their use in pregnancy and lactating mothers are covered in this review. Novel data regarding reno-protective effect of telbivudine are also discussed. Expert opinion: Use of NA in HBV is generally safe. Uncommon adverse effects can be minimized or detected early if clinicians exercise adequate precautions when using NA for at-risk populations with regular monitoring. | - |
dc.language | eng | - |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eds | - |
dc.relation.ispartof | Expert Opinion on Drug Safety | - |
dc.rights | Expert Opinion on Drug Safety. Copyright © Informa Healthcare. | - |
dc.subject | Breast feeding | - |
dc.subject | Chronic hepatitis B | - |
dc.subject | DNA polymerase inhibitor | - |
dc.subject | Fanconi syndrome | - |
dc.subject | Lactic acidosis | - |
dc.subject | Muscle toxicity | - |
dc.subject | Myopathy | - |
dc.subject | Nephrotoxicity | - |
dc.subject | Nucleoside/ nucleotide analogue | - |
dc.subject | Osteomalacia | - |
dc.subject | Peripheral neuropathy | - |
dc.subject | Teratogenecity | - |
dc.title | DNA polymerase inhibitors for treating hepatitis B: a safety evaluation | - |
dc.type | Article | - |
dc.identifier.email | Mak, LY: lungyi@hku.hk | - |
dc.identifier.email | Seto, WK: wkseto@hku.hk | - |
dc.identifier.email | Lai, CL: hrmelcl@hkucc.hku.hk | - |
dc.identifier.email | Yuen, MF: mfyuen@hku.hk | - |
dc.identifier.authority | Mak, LY=rp02668 | - |
dc.identifier.authority | Seto, WK=rp01659 | - |
dc.identifier.authority | Lai, CL=rp00314 | - |
dc.identifier.authority | Yuen, MF=rp00479 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1517/14740338.2016.1139573 | - |
dc.identifier.pmid | 26752687 | - |
dc.identifier.scopus | eid_2-s2.0-84959509417 | - |
dc.identifier.hkuros | 258632 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 383 | - |
dc.identifier.epage | 392 | - |
dc.identifier.isi | WOS:000371330700002 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1474-0338 | - |