File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Loneliness in late-life depression: Structural and functional connectivity during affective processing

TitleLoneliness in late-life depression: Structural and functional connectivity during affective processing
Authors
KeywordsConnectivity
DTI
fMRI
Late-life depression
Loneliness
Issue Date2016
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2016, v. 46 n. 12, p. 2485-2499 How to Cite?
AbstractBackground: Late-life depression (LLD) in the elderly was reported to present with emotion dysregulation accompanied by high perceived loneliness. Previous research has suggested that LLD is a disorder of connectivity and is associated with aberrant network properties. On the other hand, perceived loneliness is found to adversely affect the brain, but little is known about its neurobiological basis in LLD. The current study investigated the relationships between the structural connectivity, functional connectivity during affective processing, and perceived loneliness in LLD. Method: The current study included 54 participants aged >60 years of whom 31 were diagnosed with LLD. Diffusion tensor imaging (DTI) data and task-based functional magnetic resonance imaging (fMRI) data of an affective processing task were collected. Network-based statistics and graph theory techniques were applied, and the participants’ perceived loneliness and depression level were measured. The affective processing task included viewing affective stimuli. Results: Structurally, a loneliness-related sub-network was identified across all subjects. Functionally, perceived loneliness was related to connectivity differently in LLD than that in controls when they were processing negative stimuli, with aberrant networking in subcortical area. Conclusions: Perceived loneliness was identified to have a unique role in relation to the negative affective processing in LLD at the functional brain connectional and network levels. The findings increas our understanding of LLD and provide initial evidence of the neurobiological mechanisms of loneliness in LLD. Loneliness might be a potential intervention target in depressive patients.
Persistent Identifierhttp://hdl.handle.net/10722/232946
ISSN
2019 Impact Factor: 5.813
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, NML-
dc.contributor.authorLiu, HL-
dc.contributor.authorLin, C-
dc.contributor.authorHuang, CM-
dc.contributor.authorWai, YY-
dc.contributor.authorLee, SH-
dc.contributor.authorLee, TMC-
dc.date.accessioned2016-09-20T05:33:33Z-
dc.date.available2016-09-20T05:33:33Z-
dc.date.issued2016-
dc.identifier.citationPsychological Medicine, 2016, v. 46 n. 12, p. 2485-2499-
dc.identifier.issn0033-2917-
dc.identifier.urihttp://hdl.handle.net/10722/232946-
dc.description.abstractBackground: Late-life depression (LLD) in the elderly was reported to present with emotion dysregulation accompanied by high perceived loneliness. Previous research has suggested that LLD is a disorder of connectivity and is associated with aberrant network properties. On the other hand, perceived loneliness is found to adversely affect the brain, but little is known about its neurobiological basis in LLD. The current study investigated the relationships between the structural connectivity, functional connectivity during affective processing, and perceived loneliness in LLD. Method: The current study included 54 participants aged >60 years of whom 31 were diagnosed with LLD. Diffusion tensor imaging (DTI) data and task-based functional magnetic resonance imaging (fMRI) data of an affective processing task were collected. Network-based statistics and graph theory techniques were applied, and the participants’ perceived loneliness and depression level were measured. The affective processing task included viewing affective stimuli. Results: Structurally, a loneliness-related sub-network was identified across all subjects. Functionally, perceived loneliness was related to connectivity differently in LLD than that in controls when they were processing negative stimuli, with aberrant networking in subcortical area. Conclusions: Perceived loneliness was identified to have a unique role in relation to the negative affective processing in LLD at the functional brain connectional and network levels. The findings increas our understanding of LLD and provide initial evidence of the neurobiological mechanisms of loneliness in LLD. Loneliness might be a potential intervention target in depressive patients.-
dc.languageeng-
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM-
dc.relation.ispartofPsychological Medicine-
dc.subjectConnectivity-
dc.subjectDTI-
dc.subjectfMRI-
dc.subjectLate-life depression-
dc.subjectLoneliness-
dc.titleLoneliness in late-life depression: Structural and functional connectivity during affective processing-
dc.typeArticle-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1017/S0033291716001033-
dc.identifier.pmid27328861-
dc.identifier.scopuseid_2-s2.0-84975317736-
dc.identifier.hkuros264794-
dc.identifier.volume46-
dc.identifier.issue12-
dc.identifier.spage2485-
dc.identifier.epage2499-
dc.identifier.isiWOS:000382567600003-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats