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Article: A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

TitleA small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells
Authors
Liu, PLi, STShen, FKo, WHYao, XQYang, D
Issue Date2016
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2016, v. 52 n. 46, p. 7380-7383 How to Cite?
DOI: http://dx.doi.org/10.1039/C6CC01964A
AbstractA C2 symmetric small molecule composed of L-phenylalanine and isophthalamide was found to function as a Cl−/HCO3− dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.
Persistent Identifierhttp://hdl.handle.net/10722/234500
ISSN
1359-7345
2021 Impact Factor: 6.065
2020 SCImago Journal Rankings: 1.837
ISI Accession Number ID
WOS:000378003100013

 

DC FieldValueLanguage
dc.contributor.authorLiu, P-
dc.contributor.authorLi, ST-
dc.contributor.authorShen, F-
dc.contributor.authorKo, WH-
dc.contributor.authorYao, XQ-
dc.contributor.authorYang, D-
dc.date.accessioned2016-10-14T13:47:17Z-
dc.date.available2016-10-14T13:47:17Z-
dc.date.issued2016-
dc.identifier.citationChemical Communications, 2016, v. 52 n. 46, p. 7380-7383-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/234500-
dc.description.abstractA C2 symmetric small molecule composed of L-phenylalanine and isophthalamide was found to function as a Cl−/HCO3− dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp-
dc.relation.ispartofChemical Communications-
dc.titleA small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells-
dc.typeArticle-
dc.identifier.emailYang, D: yangdan@hku.hk-
dc.identifier.authorityYang, D=rp00825-
dc.description.naturepostprint-
dc.identifier.doi10.1039/C6CC01964A-
dc.identifier.scopuseid_2-s2.0-84973395003-
dc.identifier.hkuros269240-
dc.identifier.volume52-
dc.identifier.issue46-
dc.identifier.spage7380-
dc.identifier.epage7383-
dc.identifier.isiWOS:000378003100013-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1359-7345-

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