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Article: Photothermally targeted thermosensitive polymer-masked nanoparticles

TitlePhotothermally targeted thermosensitive polymer-masked nanoparticles
Authors
Keywordstemperature-responsive
YIGSR
pNIPAAm
Au nanoshells
phototargeting
shielding
Issue Date2014
Citation
Nano Letters, 2014, v. 14, n. 7, p. 3697-3701 How to Cite?
AbstractThe targeted delivery of therapeutic cargos using noninvasive stimuli has the potential to improve efficacy and reduce off-target effects (toxicity). Here, we demonstrate a targeting mechanism that uses a thermoresponsive copolymer to mask a peptide ligand that binds a widely distributed receptor (integrin β1) on the surface of silica core-gold shell nanoparticles. The nanoparticles convert NIR light into heat, which causes the copolymer to collapse, exposing the ligand peptide, allowing cell binding. The use of NIR light could allow targeting of plasmonic nanoparticles deep within tissues. This approach could be extended to a variety of applications including photothermal therapy and drug delivery. © 2014 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/236722
ISSN
2017 Impact Factor: 12.08
2015 SCImago Journal Rankings: 9.006
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBarhoumi, Aoune-
dc.contributor.authorWang, Weiping-
dc.contributor.authorZurakowski, David-
dc.contributor.authorLanger, Robert S.-
dc.contributor.authorKohane, Daniel S.-
dc.date.accessioned2016-12-02T03:07:29Z-
dc.date.available2016-12-02T03:07:29Z-
dc.date.issued2014-
dc.identifier.citationNano Letters, 2014, v. 14, n. 7, p. 3697-3701-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/236722-
dc.description.abstractThe targeted delivery of therapeutic cargos using noninvasive stimuli has the potential to improve efficacy and reduce off-target effects (toxicity). Here, we demonstrate a targeting mechanism that uses a thermoresponsive copolymer to mask a peptide ligand that binds a widely distributed receptor (integrin β1) on the surface of silica core-gold shell nanoparticles. The nanoparticles convert NIR light into heat, which causes the copolymer to collapse, exposing the ligand peptide, allowing cell binding. The use of NIR light could allow targeting of plasmonic nanoparticles deep within tissues. This approach could be extended to a variety of applications including photothermal therapy and drug delivery. © 2014 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.subjecttemperature-responsive-
dc.subjectYIGSR-
dc.subjectpNIPAAm-
dc.subjectAu nanoshells-
dc.subjectphototargeting-
dc.subjectshielding-
dc.titlePhotothermally targeted thermosensitive polymer-masked nanoparticles-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1021/nl403733z-
dc.identifier.pmid24884872-
dc.identifier.scopuseid_2-s2.0-84903975574-
dc.identifier.volume14-
dc.identifier.issue7-
dc.identifier.spage3697-
dc.identifier.epage3701-
dc.identifier.eissn1530-6992-
dc.identifier.isiWOS:000338979700001-

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