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Article: Enhanced precision of nanoparticle phototargeting in vivo at a safe irradiance

TitleEnhanced precision of nanoparticle phototargeting in vivo at a safe irradiance
Authors
Keywordsphototargeted nanoparticles
photoresponsive binding
photon upconversion
photocleavage
Caged ligands
Issue Date2016
Citation
Nano Letters, 2016, v. 16, n. 7, p. 4516-4520 How to Cite?
Abstract© 2016 American Chemical Society.A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm2) over a short period (5 min) using green light.
Persistent Identifierhttp://hdl.handle.net/10722/236727
ISSN
2017 Impact Factor: 12.08
2015 SCImago Journal Rankings: 9.006
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Qian-
dc.contributor.authorWang, Weiping-
dc.contributor.authorZhan, Changyou-
dc.contributor.authorYang, Tianshe-
dc.contributor.authorKohane, Daniel S.-
dc.date.accessioned2016-12-02T03:07:29Z-
dc.date.available2016-12-02T03:07:29Z-
dc.date.issued2016-
dc.identifier.citationNano Letters, 2016, v. 16, n. 7, p. 4516-4520-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/236727-
dc.description.abstract© 2016 American Chemical Society.A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm2) over a short period (5 min) using green light.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.subjectphototargeted nanoparticles-
dc.subjectphotoresponsive binding-
dc.subjectphoton upconversion-
dc.subjectphotocleavage-
dc.subjectCaged ligands-
dc.titleEnhanced precision of nanoparticle phototargeting in vivo at a safe irradiance-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.nanolett.6b01730-
dc.identifier.scopuseid_2-s2.0-84978708876-
dc.identifier.volume16-
dc.identifier.issue7-
dc.identifier.spage4516-
dc.identifier.epage4520-
dc.identifier.eissn1530-6992-
dc.identifier.isiWOS:000379794200079-

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