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Conference Paper: Bleeding-related hospital admissions and 30-day re-admissions with dabigatran versus warfarin in patients with nonvalvular atrial fibrillation

TitleBleeding-related hospital admissions and 30-day re-admissions with dabigatran versus warfarin in patients with nonvalvular atrial fibrillation
Authors
Issue Date2017
PublisherElsevier Inc. The Journal's web site is located at http://www.valueinhealthjournal.com/
Citation
22nd International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Annual International Meeting, Boston, USA, 20-24 May 2017. In Value in Health, 2017, v. 20 n. 5, p. A263, abstract no. PCV27 How to Cite?
AbstractOBJECTIVES: To compare the incidence of bleeding-related hospital admissions and 30-day re-admissions with dabigatran versus warfarin in patients with nonvalvular atrial fibrillation (NVAF). METHODS: Retrospective cohort study using a population-wide database managed by the Hong Kong Hospital Authority. Patients newly diagnosed with NVAF from 2010 through 2014 and prescribed dabigatran or warfarin were 1:1 matched by propensity score. The incidence rate of hospital admission with bleeding (a composite of gastrointestinal bleeding, intracranial hemorrhage, and bleeding at other sites) was assessed by zeroinflated negative binomial regression. Among patients who were continuously prescribed with their initial anticoagulants upon discharge, we assessed the risk of 30-day re-admission with bleeding using a Cox proportional hazard regression model, with adjustment for length of stay and type of bleeding in the initial bleeding episode. RESULTS: Preliminary results indicated that among the 51946 patients with NVAF, 8309 users of dabigatran or warfarin were identified, with 5160 patients matched by propensity score. Of these, 151 (5.9%) dabigatran users and 172 (6.7%) warfarin users were hospitalized with bleeding during follow-up. The incidence of first hospitalized bleeding did not differ significantly between groups (incidence rate ratio[IRR]: 0.92; 95% confidence interval[CI]: 0.66-1.28). Cox regression analysis indicated that dabigatran use was associated with a higher risk of 30-day re-admission with bleeding over warfarin (adjusted hazard ratio [HR]: 2.87; 95%CI: 1.10-7.43). The difference became statistically nonsignificant when the observation period was extended to 60 days of discharge (HR: 1.89; 95%CI: 0.89-4.04). CONCLUSIONS: When compared to warfarin, dabigatran was associated with a comparable incidence of hospital admission but a higher risk of 30-day re-admission with respect to bleeding. Given that dabigatran achieves full anticoagulation more quickly than warfarin, close early monitoring of patients initiated on dabigatran following hospital discharge for bleeding is warranted.
DescriptionPoster Presentations Session IV - Cardiovascular Disorders - Clinical Outcomes Studies - no. PCV27
Persistent Identifierhttp://hdl.handle.net/10722/241805
ISSN
2019 Impact Factor: 4.748
2015 SCImago Journal Rankings: 1.645

 

DC FieldValueLanguage
dc.contributor.authorLau, CY-
dc.contributor.authorLi, X-
dc.contributor.authorWong, ICK-
dc.contributor.authorChan, EW-
dc.date.accessioned2017-06-20T01:48:49Z-
dc.date.available2017-06-20T01:48:49Z-
dc.date.issued2017-
dc.identifier.citation22nd International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Annual International Meeting, Boston, USA, 20-24 May 2017. In Value in Health, 2017, v. 20 n. 5, p. A263, abstract no. PCV27-
dc.identifier.issn1098-3015-
dc.identifier.urihttp://hdl.handle.net/10722/241805-
dc.descriptionPoster Presentations Session IV - Cardiovascular Disorders - Clinical Outcomes Studies - no. PCV27-
dc.description.abstractOBJECTIVES: To compare the incidence of bleeding-related hospital admissions and 30-day re-admissions with dabigatran versus warfarin in patients with nonvalvular atrial fibrillation (NVAF). METHODS: Retrospective cohort study using a population-wide database managed by the Hong Kong Hospital Authority. Patients newly diagnosed with NVAF from 2010 through 2014 and prescribed dabigatran or warfarin were 1:1 matched by propensity score. The incidence rate of hospital admission with bleeding (a composite of gastrointestinal bleeding, intracranial hemorrhage, and bleeding at other sites) was assessed by zeroinflated negative binomial regression. Among patients who were continuously prescribed with their initial anticoagulants upon discharge, we assessed the risk of 30-day re-admission with bleeding using a Cox proportional hazard regression model, with adjustment for length of stay and type of bleeding in the initial bleeding episode. RESULTS: Preliminary results indicated that among the 51946 patients with NVAF, 8309 users of dabigatran or warfarin were identified, with 5160 patients matched by propensity score. Of these, 151 (5.9%) dabigatran users and 172 (6.7%) warfarin users were hospitalized with bleeding during follow-up. The incidence of first hospitalized bleeding did not differ significantly between groups (incidence rate ratio[IRR]: 0.92; 95% confidence interval[CI]: 0.66-1.28). Cox regression analysis indicated that dabigatran use was associated with a higher risk of 30-day re-admission with bleeding over warfarin (adjusted hazard ratio [HR]: 2.87; 95%CI: 1.10-7.43). The difference became statistically nonsignificant when the observation period was extended to 60 days of discharge (HR: 1.89; 95%CI: 0.89-4.04). CONCLUSIONS: When compared to warfarin, dabigatran was associated with a comparable incidence of hospital admission but a higher risk of 30-day re-admission with respect to bleeding. Given that dabigatran achieves full anticoagulation more quickly than warfarin, close early monitoring of patients initiated on dabigatran following hospital discharge for bleeding is warranted.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.valueinhealthjournal.com/-
dc.relation.ispartofValue in Health-
dc.titleBleeding-related hospital admissions and 30-day re-admissions with dabigatran versus warfarin in patients with nonvalvular atrial fibrillation-
dc.typeConference_Paper-
dc.identifier.emailLi, X: sxueli@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailChan, EW: ewchan@hku.hk-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityChan, EW=rp01587-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.jval.2017.05.005-
dc.identifier.hkuros272629-
dc.identifier.volume20-
dc.identifier.issue5-
dc.identifier.spageA263, abstract no. PCV27-
dc.identifier.epageA263, abstract no. PCV27-
dc.publisher.placeUnited States-

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