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Article: Prescribing trends and indications of antipsychotic medication in Hong Kong from 2004 to 2014: General and vulnerable patient groups

TitlePrescribing trends and indications of antipsychotic medication in Hong Kong from 2004 to 2014: General and vulnerable patient groups
Authors
KeywordsAntipsychotic
Children
Elderly
Pregnancy
Prescribing trend
Prevalence
Issue Date2017
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669
Citation
Pharmacoepidemiology and Drug Safety, 2017, v. 26 n. 11, p. 1387-1394 How to Cite?
AbstractPURPOSE: Antipsychotic-prescribing patterns remain unclear in Asia. The aims of our study were to investigate prescribing trends of antipsychotic medication in the general population, children, and older patients by drug generation (first or second), the prescribing trend in pregnant women, the probable indication for antipsychotic prescription, and the prescribing trend by dosage form. METHODS: This descriptive study identified and included all patients prescribed with antipsychotic in Hong Kong from 2004 to 2014 using the Clinical Data Analysis and Report System. This study calculated and reported the prevalence of antipsychotic prescribing in patient groups of interest, the percentage with diagnoses of mental disorders were derived, and the prevalence of antipsychotic by dosage forms. RESULTS: The study included 10 109 206 prescriptions of any antipsychotics to 256 903 patients. Over the study period, the prevalence of antipsychotic prescribing increased from 1.06% to 1.54% in the general population, from 0.10% to 0.23% in children (3-17 years old), and from 2.61% to 3.26% in older patients (≥65 years old). The prevalence of second-generation antipsychotics increased, but the prevalence of first-generation antipsychotics did not. Prevalence of antipsychotic prescribing in prepregnancy, pregnancy, and postpartum timeframes varied from 0.18% to 0.38%. The percentage of incident prescriptions with a diagnosis of psychosis decreased from 54.1% to 47.5%. CONCLUSIONS: Antipsychotics have been increasingly prescribed in the general population, children, and older patients. There is an increase in second-generation antipsychotic prescribing. Over half of incident users had a recent diagnosis of a nonpsychotic mental disorder in 2014, suggesting that off-label prescribing of antipsychotics might be common. Copyright © 2017 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/242034
ISSN
2019 Impact Factor: 2.918
2015 SCImago Journal Rankings: 1.804
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLao, S-
dc.contributor.authorTam, AW-
dc.contributor.authorWong, ICK-
dc.contributor.authorBesag, FMC-
dc.contributor.authorMan, KCK-
dc.contributor.authorChui, SLC-
dc.contributor.authorChan, EW-
dc.date.accessioned2017-07-18T02:52:03Z-
dc.date.available2017-07-18T02:52:03Z-
dc.date.issued2017-
dc.identifier.citationPharmacoepidemiology and Drug Safety, 2017, v. 26 n. 11, p. 1387-1394-
dc.identifier.issn1053-8569-
dc.identifier.urihttp://hdl.handle.net/10722/242034-
dc.description.abstractPURPOSE: Antipsychotic-prescribing patterns remain unclear in Asia. The aims of our study were to investigate prescribing trends of antipsychotic medication in the general population, children, and older patients by drug generation (first or second), the prescribing trend in pregnant women, the probable indication for antipsychotic prescription, and the prescribing trend by dosage form. METHODS: This descriptive study identified and included all patients prescribed with antipsychotic in Hong Kong from 2004 to 2014 using the Clinical Data Analysis and Report System. This study calculated and reported the prevalence of antipsychotic prescribing in patient groups of interest, the percentage with diagnoses of mental disorders were derived, and the prevalence of antipsychotic by dosage forms. RESULTS: The study included 10 109 206 prescriptions of any antipsychotics to 256 903 patients. Over the study period, the prevalence of antipsychotic prescribing increased from 1.06% to 1.54% in the general population, from 0.10% to 0.23% in children (3-17 years old), and from 2.61% to 3.26% in older patients (≥65 years old). The prevalence of second-generation antipsychotics increased, but the prevalence of first-generation antipsychotics did not. Prevalence of antipsychotic prescribing in prepregnancy, pregnancy, and postpartum timeframes varied from 0.18% to 0.38%. The percentage of incident prescriptions with a diagnosis of psychosis decreased from 54.1% to 47.5%. CONCLUSIONS: Antipsychotics have been increasingly prescribed in the general population, children, and older patients. There is an increase in second-generation antipsychotic prescribing. Over half of incident users had a recent diagnosis of a nonpsychotic mental disorder in 2014, suggesting that off-label prescribing of antipsychotics might be common. Copyright © 2017 John Wiley & Sons, Ltd.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669-
dc.relation.ispartofPharmacoepidemiology and Drug Safety-
dc.rightsPharmacoepidemiology and Drug Safety. Copyright © John Wiley & Sons Ltd.-
dc.rightsThis is the peer reviewed version of the following article: Pharmacoepidemiology and Drug Safety, 2017, v. 26 n. 11, p. 1387-1394, which has been published in final form at https://doi.org/10.1002/pds.4244. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.-
dc.subjectAntipsychotic-
dc.subjectChildren-
dc.subjectElderly-
dc.subjectPregnancy-
dc.subjectPrescribing trend-
dc.subjectPrevalence-
dc.titlePrescribing trends and indications of antipsychotic medication in Hong Kong from 2004 to 2014: General and vulnerable patient groups-
dc.typeArticle-
dc.identifier.emailTam, AW: awtam@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailMan, KCK: mkckth@hku.hk-
dc.identifier.emailChui, SLC: cceline@connect.hku.hk-
dc.identifier.emailChan, EW: ewchan@hku.hk-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityChan, EW=rp01587-
dc.description.naturepostprint-
dc.identifier.doi10.1002/pds.4244-
dc.identifier.pmid28665012-
dc.identifier.scopuseid_2-s2.0-85021735183-
dc.identifier.hkuros273795-
dc.identifier.volume26-
dc.identifier.issue11-
dc.identifier.spage1387-
dc.identifier.epage1394-
dc.identifier.isiWOS:000414346800011-
dc.publisher.placeUnited Kingdom-

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