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Conference Paper: Anterior thoracic fatty corner lesions are useful in axial spondyloarthritis (SpA) diagnosis --- data from a multicenter back pain-MRI cohort in Hong Kong

TitleAnterior thoracic fatty corner lesions are useful in axial spondyloarthritis (SpA) diagnosis --- data from a multicenter back pain-MRI cohort in Hong Kong
Authors
Issue Date2018
PublisherBMJ Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/
Citation
Annual European Congress of Rheumatology (EULAR Congress), Amsterdam, the Netherlands, 13-16 June 2018. In Annals of the Rheumatic Diseases, 2018, v. 77 n. Suppl. 2, p. 1559 How to Cite?
AbstractBackground: A fatty corner lesion (FCL), as defined by fat infiltration at the vertebral corner in T1 Magnetic Resonance Imaging (MRI) sequence, has been reported to be useful in Spondyloarthritis (SpA) diagnosis. Objectives: Our objective is to systematically evaluate the diagnostic utility of FCLs in a large, multicenter back pain-MRI cohort in Hong Kong. Methods: Three hundred and one patients with back pain were recruited from 3 rheumatology centres. Clinical, biochemical and radiological parameters were collected and all patients underwent a whole spine and sacroiliac (SI) joints MRI. FCLs from C4 to L5 levels were scored. Results were compared to expert-diagnosed axial SpA to determine the usefulness of FCLs in disease diagnosis. Results: Anterior FCLs of whole or thoracic spine were found to be useful in axial SpA diagnosis. (AUC 0.622; p=0.003, AUC 0.640; p=0.001 respectively) Applying FCLs to the Modified New York (MNY) criteria and Assessment of SpondyloArthritis international Society (ASAS) axial SpA criteria, a minimum of 5 FCLs at whole spine level had a sensitivity of 66.4% and 91.6%, specificity of 98.4% and 91.9% respectively. Applying a minimum of 3 FCLs at thoracic spine level to the MNY criteria and ASAS axial SpA criteria yielded a sensitivity of 68.5% and 92.0%, specificity of 95.2% and 93.5% respectively. Three FCLs improves both classification criteria. Conclusions: FCLs are useful in axial SpA diagnosis. A minimum of 3FCLs at the thoracic level is useful for the disease diagnosis. Disclosure of Interest: None declared
DescriptionSession: Spondyloarthritis – clinical aspects (other than treatment): abstract no. AB0862
Organized by The European League Against Rheumatism (EULAR)
Persistent Identifierhttp://hdl.handle.net/10722/256455
ISSN
2019 Impact Factor: 16.102
2015 SCImago Journal Rankings: 4.537
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, HY-
dc.contributor.authorYiu, SWR-
dc.contributor.authorTsang, HHL-
dc.date.accessioned2018-07-20T06:34:56Z-
dc.date.available2018-07-20T06:34:56Z-
dc.date.issued2018-
dc.identifier.citationAnnual European Congress of Rheumatology (EULAR Congress), Amsterdam, the Netherlands, 13-16 June 2018. In Annals of the Rheumatic Diseases, 2018, v. 77 n. Suppl. 2, p. 1559-
dc.identifier.issn0003-4967-
dc.identifier.urihttp://hdl.handle.net/10722/256455-
dc.descriptionSession: Spondyloarthritis – clinical aspects (other than treatment): abstract no. AB0862-
dc.descriptionOrganized by The European League Against Rheumatism (EULAR)-
dc.description.abstractBackground: A fatty corner lesion (FCL), as defined by fat infiltration at the vertebral corner in T1 Magnetic Resonance Imaging (MRI) sequence, has been reported to be useful in Spondyloarthritis (SpA) diagnosis. Objectives: Our objective is to systematically evaluate the diagnostic utility of FCLs in a large, multicenter back pain-MRI cohort in Hong Kong. Methods: Three hundred and one patients with back pain were recruited from 3 rheumatology centres. Clinical, biochemical and radiological parameters were collected and all patients underwent a whole spine and sacroiliac (SI) joints MRI. FCLs from C4 to L5 levels were scored. Results were compared to expert-diagnosed axial SpA to determine the usefulness of FCLs in disease diagnosis. Results: Anterior FCLs of whole or thoracic spine were found to be useful in axial SpA diagnosis. (AUC 0.622; p=0.003, AUC 0.640; p=0.001 respectively) Applying FCLs to the Modified New York (MNY) criteria and Assessment of SpondyloArthritis international Society (ASAS) axial SpA criteria, a minimum of 5 FCLs at whole spine level had a sensitivity of 66.4% and 91.6%, specificity of 98.4% and 91.9% respectively. Applying a minimum of 3 FCLs at thoracic spine level to the MNY criteria and ASAS axial SpA criteria yielded a sensitivity of 68.5% and 92.0%, specificity of 95.2% and 93.5% respectively. Three FCLs improves both classification criteria. Conclusions: FCLs are useful in axial SpA diagnosis. A minimum of 3FCLs at the thoracic level is useful for the disease diagnosis. Disclosure of Interest: None declared-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/-
dc.relation.ispartofAnnals of the Rheumatic Diseases-
dc.relation.ispartofAnnual European Congress of Rheumatology (EULAR Congress)-
dc.rightsAnnals of the Rheumatic Diseases. Copyright © BMJ Publishing Group.-
dc.titleAnterior thoracic fatty corner lesions are useful in axial spondyloarthritis (SpA) diagnosis --- data from a multicenter back pain-MRI cohort in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailChung, HY: jameschy@hku.hk-
dc.identifier.authorityChung, HY=rp02330-
dc.identifier.doi10.1136/annrheumdis-2018-eular.1757-
dc.identifier.hkuros286166-
dc.identifier.volume77-
dc.identifier.issueSuppl. 2-
dc.identifier.spage1559-
dc.identifier.epage1559-
dc.identifier.isiWOS:000444351004444-
dc.publisher.placeUnited Kingdom-

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